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A Study of Prognostic Value of Hs-CRP and Fibrinogen in Patients of Unstable Angina


Affiliations
1 Department of Medicine, Government Medical College, Amritsar, Punjab, India
2 UPHC Ram Bagh, Amritsar, Punjab, India
3 PHC Panjkosi, Khuikhera, Punjab, India
 

Background: Unstable angina constitutes a clinical syndrome that is usually caused by atherosclerotic coronary artery disease and is associated with an increased risk of cardiac death and myocardial infarction.

Material and Methods: An open, prospective, observational, comparative study was conducted. The study included 50 cases in age group 20-80 years admitted in Government Medical College, Amritsar diagnosed as unstable angina ruled out by Trop T and CPK-MB at admission. Hs-CRP and Fibrinogen levels were estimated at time of admission and repeated after 48 hours.

Results: There was significant difference in the mean value of Hs-CRP between favourable and unfavourable group at the time of admission (0.807±0.37mg/l v/s 3.57±1.70mg/l, p<0.001). A significant difference in the mean value of Hs-CRP was found between favourable and unfavourable group after 48 hours (0.51±0.22mg/l v/s 4.03±1.84mg/l, p<0.001) There was significant difference in the mean value of fibrinogen between favourable and unfavourable group at the time of admission (356.94±72.50mg/dl v/s 588.60±94.89mg/dl, p<0.001). A significant difference in the mean value of fibrinogen was found between favourable and unfavourable group after 48 hours (309.11±75.25mg/dl v/s 622.60±133.42mg/dl, p<0.001).

Conclusion: It is concluded that in patients with unstable angina, elevated levels of Hs-CRP and Fibrinogen at admission indicate an adverse hospital outcome.


Keywords

Hs-CRP, Unstable Angina, Fibrinogen, Myocardial Infarction, Coronary Artery Disease.
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  • A Study of Prognostic Value of Hs-CRP and Fibrinogen in Patients of Unstable Angina

Abstract Views: 325  |  PDF Views: 130

Authors

Harpreet Singh
Department of Medicine, Government Medical College, Amritsar, Punjab, India
Kunal Bansal
Department of Medicine, Government Medical College, Amritsar, Punjab, India
Tarsem Pal Singh
Department of Medicine, Government Medical College, Amritsar, Punjab, India
Deepa Malik
Department of Medicine, Government Medical College, Amritsar, Punjab, India
Vanita Bansal
UPHC Ram Bagh, Amritsar, Punjab, India
Tushar Bansal
PHC Panjkosi, Khuikhera, Punjab, India

Abstract


Background: Unstable angina constitutes a clinical syndrome that is usually caused by atherosclerotic coronary artery disease and is associated with an increased risk of cardiac death and myocardial infarction.

Material and Methods: An open, prospective, observational, comparative study was conducted. The study included 50 cases in age group 20-80 years admitted in Government Medical College, Amritsar diagnosed as unstable angina ruled out by Trop T and CPK-MB at admission. Hs-CRP and Fibrinogen levels were estimated at time of admission and repeated after 48 hours.

Results: There was significant difference in the mean value of Hs-CRP between favourable and unfavourable group at the time of admission (0.807±0.37mg/l v/s 3.57±1.70mg/l, p<0.001). A significant difference in the mean value of Hs-CRP was found between favourable and unfavourable group after 48 hours (0.51±0.22mg/l v/s 4.03±1.84mg/l, p<0.001) There was significant difference in the mean value of fibrinogen between favourable and unfavourable group at the time of admission (356.94±72.50mg/dl v/s 588.60±94.89mg/dl, p<0.001). A significant difference in the mean value of fibrinogen was found between favourable and unfavourable group after 48 hours (309.11±75.25mg/dl v/s 622.60±133.42mg/dl, p<0.001).

Conclusion: It is concluded that in patients with unstable angina, elevated levels of Hs-CRP and Fibrinogen at admission indicate an adverse hospital outcome.


Keywords


Hs-CRP, Unstable Angina, Fibrinogen, Myocardial Infarction, Coronary Artery Disease.

References





DOI: https://doi.org/10.18311/ijmds%2F2018%2F166207