International Journal of Medical and Dental Sciences

Open Access Open Access  Restricted Access Subscription Access

Evaluation of Risk Factors for Retinopathy of Prematurity in Premature Born Infants in Tertiary Care Centre in Punjab


Affiliations
1 Department of Paediatrics, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
2 Department of Pathology, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
3 Intern Paediatrics, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
 

Background: Retinopathy of Prematurity (ROP) is a disease where development of abnormal retinal vessels occurs because of incomplete vascularization of the retinal tissue. With advancement in the field of neonatology now more premature babies and Very-Low-Birth-Weight (VLBW) infants surviving and incidence of retinopathy of prematurity is increasing. ROP screening should be done in all premature babies. Objectives: To Study the Risk Factors for Retinopathy of Prematurity in Premature Born infants at tertiary care centre. Methods: This study was done on 75 newborns infants and were included in study after satisfying the inclusion criteria. The following criteria were studied: gestational age≤34 weeks or BW≤1500 grams, along with neonates with more birth weight and higher gestational age having risk factors like : low Apgar score, duration of oxygen supplementation more than 10 days, sepsis, more than one blood transfusion, respiratory distress. Characteristics of newborns including risk factors, and pattern of severe ROP were assessed from Punjab region of India. Result: Total of 75 newborns included in the study, 53 were males (70.66%) and 22 were (29.33%) females. The analysis of gestational age showed that the mean age was 29.9±2.9 weeks, the youngest one was of 27 weeks and the oldest was 37 weeks of gestation. The average birth weight was 1350±510 grams, with lowest 675 gm and highest 3100 grams. Conclusion: The most common risk factors that are associated with development of ROP revealed gestational age, Apgar score in the first minute, birth weight, duration of oxygen therapy and the blood transfusion.

Keywords

Apgar Score, Continuous Pressure, Oxygen Duration, Respiratory Distress, CPAP.
User
Notifications
Font Size


  • Ober RR, Palmer EA, Drack AV, Wright KW. Retinopathy of prematurity. Handbook of paediatric retinal disease. 2006; 10: 284–338. https://doi.org/10.1007/0-387-279334_10.

  • Terry TL. Extreme Prematurity and Fibroblastic Overgrowth. Preliminary Report. Am J Ophthamlol. 1942; 25: 203–204. https://doi.org/10.1016/S0002-9394(42)92088-9.

  • Smith LEH. Pathogenesis of retinopathy of prematurity. Growth Hormone & IGF Research 2004. 14: 140–144. https://doi.org/10.1016/j.ghir.2004.03.030.

  • Saugstad OD. Oxygen and retinopathy of prematurity. J Perinatol. 2006; 26: 46–50. https://doi.org/10.1038/sj.jp.7211475.

  • Kinsey VE, Patz A, Stern L. Oxygen and retrolental fibroplasias: in defence of data. Paediatrics. 1978; 62: 439– 440.

  • Tin W. Oxygen therapy: 50 years of uncertainty. Pediatrics. 2002; 110: 615–616. https://doi.org/10.1542/peds.110.3.615.

  • Darlow BA, Hutchinson JL, Henderson-Smart DJ, Donoghue DA, Simpson JM, Evans NJ. Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network. Pediatrics. 2005; 115: 990–996. https://doi.org/10.1542/peds.2004-1309.

  • The Committee for the Classification of Retinopathy of Prematurity: an international classification of retinopathy of prematurity. Arch Ophthalmol. 1984; 102: 1130–1134. https://doi.org/10.1001/archopht.1984.01040030908011.

  • Vatavuk Z, Benčić G, AndrijevićDerk B, Mandić Z. Suvremeni pristup liječenju retinopatije nedonoščadi. Suvremeni dijagnostičko-terapijski postupci u oftalmologiji. Medix, listopad. 2008; 78:113–116.

  • Mutlu FM, Sadici SU. Treatment of retinopathy of prematurity: a review of conventional and promising new therapeutic option. Int J Ophthalmol. 2013; 6: 228–226.

  • Thomas K, Shah PS, Canning R, Harrison A, Lee SK, Dow KE. Retinopathy of prematurity: Risk factors and variability in Canadian neonatal intensive care units. J Neonatal Perinatal Med. 24 Oct 2015; 8(3): 207–214. https://doi.org/10.3233/NPM-15814128

  • Enomoto H, Miki A, Matsumiya W, Honda S. Evaluation of Oxygen Supplementation Status as a Risk Factor Associated with the Development of Severe Retinopathy of Prematurity. Ophthalmologica. 2015; 234(3): 135–138. https://doi.org/10.1159/000433565

  • Khalesi N, Shariat M, Fallahi M, Rostamian G. Evaluation of risk factors for retinopathy in preterm infant: a casecontrol study in a referral hospital in Iran. Minerva Pediatr. Jun 2015; 67(3): 231–237.


Abstract Views: 261

PDF Views: 136




  • Evaluation of Risk Factors for Retinopathy of Prematurity in Premature Born Infants in Tertiary Care Centre in Punjab

Abstract Views: 261  |  PDF Views: 136

Authors

Jatinder Singh
Department of Paediatrics, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
Vaneeta Bhardwar
Department of Pathology, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
Harshdhawann Singh
Intern Paediatrics, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
Isha Bhardwaj
Intern Paediatrics, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
Sushmita Choudhary
Intern Paediatrics, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India
Alka Toora
Intern Paediatrics, Punjab Institute of Medical Sciences (PIMS), Jalandhar – 14402, Punjab, India

Abstract


Background: Retinopathy of Prematurity (ROP) is a disease where development of abnormal retinal vessels occurs because of incomplete vascularization of the retinal tissue. With advancement in the field of neonatology now more premature babies and Very-Low-Birth-Weight (VLBW) infants surviving and incidence of retinopathy of prematurity is increasing. ROP screening should be done in all premature babies. Objectives: To Study the Risk Factors for Retinopathy of Prematurity in Premature Born infants at tertiary care centre. Methods: This study was done on 75 newborns infants and were included in study after satisfying the inclusion criteria. The following criteria were studied: gestational age≤34 weeks or BW≤1500 grams, along with neonates with more birth weight and higher gestational age having risk factors like : low Apgar score, duration of oxygen supplementation more than 10 days, sepsis, more than one blood transfusion, respiratory distress. Characteristics of newborns including risk factors, and pattern of severe ROP were assessed from Punjab region of India. Result: Total of 75 newborns included in the study, 53 were males (70.66%) and 22 were (29.33%) females. The analysis of gestational age showed that the mean age was 29.9±2.9 weeks, the youngest one was of 27 weeks and the oldest was 37 weeks of gestation. The average birth weight was 1350±510 grams, with lowest 675 gm and highest 3100 grams. Conclusion: The most common risk factors that are associated with development of ROP revealed gestational age, Apgar score in the first minute, birth weight, duration of oxygen therapy and the blood transfusion.

Keywords


Apgar Score, Continuous Pressure, Oxygen Duration, Respiratory Distress, CPAP.

References





DOI: https://doi.org/10.18311/ijmds%2F2020%2F24651