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Tirzepatide: Revolutionary Drug in Management of “Diabesity”


Affiliations
1 MBBS Final Prof., Punjab Institute of Medical Sciences, Jalandhar - 144006, Punjab, India
2 Professor, Department of Pharmacology, Punjab Institute of Medical Sciences, Jalandhar - 144006, Punjab, India
 

Tirzepatide, a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist has recently been approved by FDA for type 2 diabetes in adults as a single dose weekly. Tirzepatide is in phase 3 development for adults with obesity or overweight with weight-related comorbidity. Tirzepatide is also under evaluation for treatment of non-alcoholic steatohepatitis, heart failure and obstructive sleep apnea.

Keywords

GIP Agonist, GLP–1 Agonist, Incretin, Obesity, Type 2 Diabetes Mellitus.
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  • Tirzepatide: Revolutionary Drug in Management of “Diabesity”

Abstract Views: 183  |  PDF Views: 97

Authors

Vansh Chouhan
MBBS Final Prof., Punjab Institute of Medical Sciences, Jalandhar - 144006, Punjab, India
Simran Spal
MBBS Final Prof., Punjab Institute of Medical Sciences, Jalandhar - 144006, Punjab, India
Rakesh Kumar
Professor, Department of Pharmacology, Punjab Institute of Medical Sciences, Jalandhar - 144006, Punjab, India

Abstract


Tirzepatide, a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist has recently been approved by FDA for type 2 diabetes in adults as a single dose weekly. Tirzepatide is in phase 3 development for adults with obesity or overweight with weight-related comorbidity. Tirzepatide is also under evaluation for treatment of non-alcoholic steatohepatitis, heart failure and obstructive sleep apnea.

Keywords


GIP Agonist, GLP–1 Agonist, Incretin, Obesity, Type 2 Diabetes Mellitus.

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DOI: https://doi.org/10.18311/ijmds%2F2022%2F215595