![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_open_medium.gif)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_restricted_medium.gif)
Correlation of Histopathological and Anatomical Changes in Placenta with Intrauterine Growth Restriction
Subscribe/Renew Journal
Material and Methods: This study included 200 pregnant patients whose foetuses had intrauterine growth restriction and 200 patients with normal foetal growth. Gross and histopathological features of placentas of both groups were studied, analysed by student's t test and compared with chi square test. p values of < 0.05 were considered significant.
Results: Gross features, weight, thickness and calcification in study group show significant increase in value (p < 0.05) compared to control group and histopathology of placenta in study group also shows significant increase in syncytial knots formation, cytotrophoblastic proliferation, stromal fibrosis and calcification as compared to control group.
Conclusion: To conclude, whatever may be the cause of IUGR, these morphological and histopathological changes lead to decrease blood to the placenta and this restriction of blood flow ultimately causes IUGR in the foetus.
Keywords
- Kaur P, Kaushal S, Singh K, Sharma A. Placental weight, birth weight and fetal outcome in preeclampsia and normotensive pregnancy. IJPAES. 2013;3(4):30-34
- Arias F. Practical guide to high risk pregnancy and delivery. 2008;3/e :99-100
- Dhabhai P, Gupta G. Placental weight and surface area in iugr cases. Innovative Journal of Medical and Health Sciences. 2014;4(6):198-200.
- Aherne W, Dunnill MS. Quantitative aspects of placental structure. J Pathol Bacteriol. 1966; 91(1):123-39
- Cetin I, Alvino G.Intrauterine Growth Restriction: Implications for placental metabolism and transport-A review Placenta.2009;(30):77-82
- Althshuler G, Russell P, Ermochilla R. The placental pathology of small for gestational age infants. Am J Obs Gynecol. 1975;121:351-59
- Nigam JS, Mishra V, Singh P, Singh A, Chauhan S, Thakur B.Histological study of placenta in low birth baby in india.2014;4(8):79-83.
- Hemlata M, Pani Kumar M, Jankai M, Dudala SR. Histopathological evaluation of placentas in IUGR pregnancies. Asian Pac J. Health Sci. 2014;1(4):566-569.
- Kotgirwar S, Ambiye M,Athavale S,Gupta V, Trivedi S. Study of Gross and Histological features of placenta in intrauterine growth retardation. J. Anat. Soc. India2011; 60(1) :37-40
- Biswas S, Ghosh SK. Gross morphological changes of placentas associated with intrauterine growth restriction of fetuses: a case-control study. Early Human Develop. 2008;84(6):357-62.
- Meeejus G. Influence of placental size and gross abnormalities on intrauterinegrowth retardation in high-risk pregnancies. Acta Medical lituanica. 2005;12 (2):14–19 12. Barker DPJ. Fetal growth restriction: A workshop report. Clin Sci. 1998:95;115-128.
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 209
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 0