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Delayed Peripheral Neuropathy Due to Organophosphate Tri-Ortho-Cresyl Phosphate Poisoning


Affiliations
1 Department of Medicine, B J Medical College, Ahmedabad, India
     

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Introduction: 15 patients were admitted to Civil Hospital, Ahmedabad with complains of cramping pain and weakness in bilateral lower limbs. They were found to be suffering from subacute motor neuropathy.

Material And Methods: All were investigated for abnormalities in complete haemogram, blood biochemistry, B12 levels, nerve conduction studies and cholinesterase levels. Results: There was distal muscle weakness in bilateral lower limbs with loss of deep tendon reflexes in lower limbs with EMG suggestive of axonal and demyelinating neuropathy with reduced RBC cholinesterase levels. Discussion: From history and investigations it was found that the ingestion of wheat contaminated with tri-ortho-cresyl phosphate (TOCP) lead to axonal and demyelinating type of polyneuropathy.


Keywords

Delayed Neuropathy, Tri-Ortho-Cresyl Phosphate.
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  • Delayed Peripheral Neuropathy Due to Organophosphate Tri-Ortho-Cresyl Phosphate Poisoning

Abstract Views: 237  |  PDF Views: 0

Authors

K. Lakhani
Department of Medicine, B J Medical College, Ahmedabad, India
D. Makwana
Department of Medicine, B J Medical College, Ahmedabad, India
A. Shah
Department of Medicine, B J Medical College, Ahmedabad, India
N. Purohit
Department of Medicine, B J Medical College, Ahmedabad, India
V. Mori
Department of Medicine, B J Medical College, Ahmedabad, India
K. Patel
Department of Medicine, B J Medical College, Ahmedabad, India
H. Zadafiya
Department of Medicine, B J Medical College, Ahmedabad, India
M. Hada
Department of Medicine, B J Medical College, Ahmedabad, India
N. Bhalani
Department of Medicine, B J Medical College, Ahmedabad, India
S. Goswami
Department of Medicine, B J Medical College, Ahmedabad, India
R. Patel
Department of Medicine, B J Medical College, Ahmedabad, India
D. Vala
Department of Medicine, B J Medical College, Ahmedabad, India

Abstract


Introduction: 15 patients were admitted to Civil Hospital, Ahmedabad with complains of cramping pain and weakness in bilateral lower limbs. They were found to be suffering from subacute motor neuropathy.

Material And Methods: All were investigated for abnormalities in complete haemogram, blood biochemistry, B12 levels, nerve conduction studies and cholinesterase levels. Results: There was distal muscle weakness in bilateral lower limbs with loss of deep tendon reflexes in lower limbs with EMG suggestive of axonal and demyelinating neuropathy with reduced RBC cholinesterase levels. Discussion: From history and investigations it was found that the ingestion of wheat contaminated with tri-ortho-cresyl phosphate (TOCP) lead to axonal and demyelinating type of polyneuropathy.


Keywords


Delayed Neuropathy, Tri-Ortho-Cresyl Phosphate.

References