Delayed Peripheral Neuropathy Due to Organophosphate Tri-Ortho-Cresyl Phosphate Poisoning
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Introduction: 15 patients were admitted to Civil Hospital, Ahmedabad with complains of cramping pain and weakness in bilateral lower limbs. They were found to be suffering from subacute motor neuropathy.
Material And Methods: All were investigated for abnormalities in complete haemogram, blood biochemistry, B12 levels, nerve conduction studies and cholinesterase levels. Results: There was distal muscle weakness in bilateral lower limbs with loss of deep tendon reflexes in lower limbs with EMG suggestive of axonal and demyelinating neuropathy with reduced RBC cholinesterase levels. Discussion: From history and investigations it was found that the ingestion of wheat contaminated with tri-ortho-cresyl phosphate (TOCP) lead to axonal and demyelinating type of polyneuropathy.
Keywords
- Susser M, Stein Z. An outbreak of tri ortho-cresyl-phosphate poisoning in Durban. BMJ. 1957;14(2):111-120.
- Cavanagh JB. Toxic effect of TOCP on nervous system. NCBI. 1954 17:163-172.
- Smith HV, Spalding JMK. Outbreak of paralysis in morocco due to ortho cresyl phosphate poisoining- The Lancet. 1960;2(7110):1019-1021.
- Vij S, Kanagasuntheram R. Effect of tri ortho cresyl phosphate poisoining on sensory nerve terminations of slow loris. Acta neuropathologica. 1972;20(2):150-159.
- Jokanovic M, Kosanovic M, Brkic D, Vukomanovic P. Organophosphate induced delayed polyneuropathy in man- Clinical Neurology and Neurosurgery. 2011;113(1):7-10.
- Bischoff A. Ultrastructure of tri-ortho-cresyl phosphate poisoning in the chicken. Acta neuropathologica. 1970;15:142155 .
- Inoue N, Fujishiro K, Mori K, Matsuoka M. Tri-ortho-cresyl phosphate poisoning- a review of human cases. J UOEH. 1988;10(4):433-42.
- Earl CJ, Thompson RHS. Cholinesterase levels in the nervous system in tri-ortho-cresyl phosphate poisoning. Brit. J. Pharmacol. 1952;7:685.
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