The Indian Practitioner

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Co-Existence of Systemic Sclerosis and Adenocarcinoma of the Lung with Cutaneous Metastasis in Young Female Patient


Affiliations
1 Dept of Respiratory Medicine, R.N.T. Medical College, Udaipur, India
2 Department of Respiratory Medicine, R.N.T. Medical College, Udaipur, India
3 R.N.T. Medical College, Udaipur, India
4 Department of Radiodiagnosis, R.N.T. Medical College, Udaipur, India
     

   Subscribe/Renew Journal


Systemic sclerosis is a connective tissue disorder which could involve the lungs. There are various pulmonary manifestations like interstitial lung disease (UIP, NSIP), pulmonary arterial hypertension; recurrent aspiration etc. Lung malignancy is a well recognized manifestation, although rare. We are reporting a case of systemic sclerosis with adenocarcinoma of lung with cutaneous metastasis which was diagnosed simultaneously. Diagnosis of systemic sclerosis was based on clinical appearance as well as on serological tests and lung carcinoma with cutaneous metastasis was diagnosed on cytological specimen from lung and skin swelling.
Subscription Login to verify subscription
User
Notifications
Font Size


  • M. Hassoun P (2011) Lung involvement in systemic sclerosis. Presse Med 40: e3-e17.

  • Tamby M C. New insight in to the pathogenesis of systemic sclerosis. Autoimmune Rev. 2003; 2: 152-157.

  • Lee P, Alderdice c, Wilkinson S, et al. Malignancy in progressive systemic sclerosis- association with breast carcinoma. J Rheumatol. 1983; 10: 665-666.

  • Talbott JH, Barrocas M (1980) Carcinoma of the lung in progressive systemic sclerosis: a tabular review of the literature and a detailed report of the roentgenographic changes in two cases. Semin Artheritis Rheum 9: 191-217.

  • Golijan EF. Rapid review Pathology. 2nd ed. St. Louis: Mosby; 2006. P. 321-4.

  • Hidaka T, Ishii Y, Kitamura S. Clinical features of skin metastasis from lung cancer. Intern Med. 1996: 35:45962.

  • Laura Pajziti, Syzana Rexhepi Hapciu, et al. Skin metastases from lung cancer: a case report. BMC Research Notes (2015)8: 139-143.

  • Maria do Socorro Teixeira Moreira Almeida. Scleroderma Lung Disease- Other Lung Complications in Systemic Sclerosis: Almeida Rheumatology 2012, S:1.

  • LeRoy EC, Black C, Fleischmajer R, et al. (1988) Sleroderma : classification, subsets and pathogenesis. J Rheumatol 15: 202-205.

  • Le Pavec J, Launay D, Mathai SC, et al. Scleroderma lung disease. Clin Rev Allergy Immunol 40: 104-116.

  • Zatuchni J, Campbell W.N., Zarafonetis CJD. Pulmonary fibrosis and terminal bronchiolar (alveolar cell) carcinoma in Scleroderma. Cancer 1953, 6,1147-50.

  • Wooten M (2008) Systemic sclerosis and malignancy: a review of the literature. South Med J 101: 59-62.

  • Benedek TG. Neoplastic associations of rheumatic disease and rheumatic manifestations of cancer. Clin Geriatr Med. 1988; 4: 333-355.

  • Rosenthal AK, McLanghlin JK, Linet MS, et al. Scleroderma and malignancy: and epidemiologic study. Ann Rheum Dis. 1933: 52: 531-533.

  • A.K. Janmcja, Sanjeev Tandon, K.B. Gupta et al. Lung malignancy in progressive systemic sclerosis. Indian Journal of Tuberculosis; 1998, 45, 161-163.

  • Biefield P. Sclerodermie systemique et cancers: 21 observation et revue de la literature. Rev Med Interne. 1996; 17: 810-813.

  • Pearson JE, Silman AJ. Risk of cancer in patients with scleroderma. Amm Rheum Dis. 2003; 62: 697-700.

  • Higuchi M. Anticentromere antibodies as a risk factor for cancer in patients with systemic sclerosis. Clin Rheumatol. 2000; 19:123-126.

  • Kyndt X, Hebbar M, Queyrel V, et al. Scleodermie systemique et cancer. Recherch de facteur predcictifs de cancer chez 123 patients sclerodermiques. Rev Med Interne 1997; 18: 528-532.

  • Hebbar M, Lassalle P, Janim A, et al. E-selectin expression in salivary endothelial cells and sera of patients with systemic sclerosis. Role of resident mast cellderived tumor necrosis factor alpha. Arthritis Rheum. 1955; 38: 406-412.

  • Koch AE, Halloran MM, Haskell CJ, et al. Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature. 1995; 376: 517-519.


Abstract Views: 278

PDF Views: 1




  • Co-Existence of Systemic Sclerosis and Adenocarcinoma of the Lung with Cutaneous Metastasis in Young Female Patient

Abstract Views: 278  |  PDF Views: 1

Authors

M. K. Arya
Dept of Respiratory Medicine, R.N.T. Medical College, Udaipur, India
N. Damor
Department of Respiratory Medicine, R.N.T. Medical College, Udaipur, India
K. Gehlot
R.N.T. Medical College, Udaipur, India
H. K. Sharma
Department of Radiodiagnosis, R.N.T. Medical College, Udaipur, India

Abstract


Systemic sclerosis is a connective tissue disorder which could involve the lungs. There are various pulmonary manifestations like interstitial lung disease (UIP, NSIP), pulmonary arterial hypertension; recurrent aspiration etc. Lung malignancy is a well recognized manifestation, although rare. We are reporting a case of systemic sclerosis with adenocarcinoma of lung with cutaneous metastasis which was diagnosed simultaneously. Diagnosis of systemic sclerosis was based on clinical appearance as well as on serological tests and lung carcinoma with cutaneous metastasis was diagnosed on cytological specimen from lung and skin swelling.

References