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Recurrent Episode of Priapism due to Quetiapine in a Bipolar Patient


Affiliations
1 Griffin Memorial Hospital, Oklahoma, United States
2 North Penn Cardiovascular Institute, United States
3 Medical College, Baroda, India
4 Chapadia Medical Center, India
5 Miller School of Medicine, Miami, United States
     

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Priapism is a rare side effect of anti-psychotics. Both typical and atypical anti-psychotics can cause priapism. Priapism means persistent and most of the times painful penile erection not associated with sexual stimulation. Priapism can cause urinary retention, cavernosa fibrosis, gangrene and even impotency if it is not treated properly in time. About 50% of priapism patients end up having impotency1. Drugs account for 25-40% of priapism2. The most common drugs causing priapism are anti-hypertensives and anti-psychotics1.

In anti-psychotics, second generation anti-psychotics are more associated with priapism. But the information in the literature is limited. Most common anti-psychotics causing priapism are Risperidone, Olanzapine and Quetiapine. We are reporting a case of recurrent episode of priapism due to Quetiapine use.


Keywords

Priapism, Bipolar Disorder, Anti-Psychotics.
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  • Thompson JW, Jr, Ware MR, Blashfield RK. Psychotropic medication and priapism: a comprehensive review. J Clin Psychiatry. 1990;51(10):430–433

  • Penaskovic, Kenan M., Fasiha Haq, and Shakeel Raza. “Priapism During Treatment With Olanzapine, Quetiapine, and Risperidone in a Patient With Schizophrenia: A Case Report.” Primary Care Companion to The Journal of Clinical Psychiatry 12.5 (2010): PCC.09l00939. PMC. Web. 29 Mar. 2016.

  • Jackson JC, Torrence CL. Quetiapine-induced Priapism Requiring Frequent Emergency Admissions: A Case Report. Urology Case Reports. 2015;3(1):1-2. doi:10.1016/j.eucr.2014.09.003.

  • M.J. Geraci, S.L. McCoy, P.M. Crum, et al. Anti-psychoticinduced priapism in an HIV patient: a cytochrome P450mediated drug interaction Int J Emerg Med, 3 (2010), pp. 81–84.


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  • Recurrent Episode of Priapism due to Quetiapine in a Bipolar Patient

Abstract Views: 277  |  PDF Views: 1

Authors

A. Vadhera
Griffin Memorial Hospital, Oklahoma, United States
K. Patel
North Penn Cardiovascular Institute, United States
H. Chapadia
Medical College, Baroda, India
C. Chapadia
Chapadia Medical Center, India
R. Chauhan
Miller School of Medicine, Miami, United States

Abstract


Priapism is a rare side effect of anti-psychotics. Both typical and atypical anti-psychotics can cause priapism. Priapism means persistent and most of the times painful penile erection not associated with sexual stimulation. Priapism can cause urinary retention, cavernosa fibrosis, gangrene and even impotency if it is not treated properly in time. About 50% of priapism patients end up having impotency1. Drugs account for 25-40% of priapism2. The most common drugs causing priapism are anti-hypertensives and anti-psychotics1.

In anti-psychotics, second generation anti-psychotics are more associated with priapism. But the information in the literature is limited. Most common anti-psychotics causing priapism are Risperidone, Olanzapine and Quetiapine. We are reporting a case of recurrent episode of priapism due to Quetiapine use.


Keywords


Priapism, Bipolar Disorder, Anti-Psychotics.

References