Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Melioidosis:A Great Mimicker


Affiliations
1 Internal Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
2 Family Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
     

   Subscribe/Renew Journal


Melioidosis is an infectious disease of humans and animals, caused by Burkholderia pseudomallei, a gram-negative soil bacterium. It is a disease of tropical climates with reports from North east and South India. It has also been listed as potential bioterrorism weapon. The bacterium causing melioidosis is found in contaminated water and soil. It spreads to humans through inhalation or inoculation.

With clinical presentations ranging from asymptomatic infection to full blown sepsis syndrome with very high mortality rate, early diagnosis and prompt treatment is important to reduce mortality.

Melioidosis is under reported in India, as it needs a high index of suspicion along with the isolation and identification of B. pseudomallei from blood and secretions.


Subscription Login to verify subscription
User
Notifications
Font Size


  • Inglis TJ, Rolim DB, Rodriguez JL. Clinical guideline for diagnosis and management of melioidosis. Rev Inst Med Trop Sao Paulo. 2006 Jan-Feb; 48(1):1-4. Epub 2006 Mar 9.
  • Inglis TJ, Golledge CL, Clair A, Harvey J. Case report: recovery from persistent septicemic melioidosis. Am J Trop Med Hyg. 2001 Jul; 65(1):76-82.
  • Ngauy V, Lemeshev Y, Sadkowski L, Crawford G. Cutaneous melioidosis in a man who was taken as a prisoner of war by the Japanese during World War II. J Clin Microbiol. 2005 Feb; 43(2):970-2.
  • Dhiensiri T, Eua-Ananta Y. Visceral abscess in melioidosis. J Med Assoc Thai. 1995 May; 78(5):225-31.
  • Inglis TJ. Principia aetiologica: taking causality beyond Koch’s postulates. J Med Microbiol. 2007 Nov; 56(Pt 11):141922.
  • White, N.J.; Dance, D.A.B.; Chaowagul, W. Et Al. - Halving Of Mortality Of Severe Melioidosis By Ceftazidime. Lancet, 2: 697-701, 1989. Treatment table
  • Currie, B.J.; Fisher, D.A.; Howard, D.M. et al. - The epidemiology of Melioidosis in Australia and Papua New Guinea. Acta trop., 74: 121-127, 2000. signs table
  • Dance, D.A.B.; Wuthiekanun, V.; Naigowit, P. & White, N.J. - Identification of Pseudomonas pseudomallei in clinical practice: use of simple screening tests and API 20NE. J. clin. Path., 42: 645-648, 1989.
  • Howard, K. & Inglis, T. - Novel selective medium for isolation of Burkholderia pseudomallei. J. clin. Microbiol., 41: 3312-3316, 2003.
  • Inglis, T.J.J.; Merritt, A.; Chidlow, G.; Aravena-Roman, M. & Harnett, G. - Comparison of diagnostic laboratory methods for identification of Burkholderia pseudomallei. J. clin. Microbiol., 43: 2201-2206, 2005.
  • Leelarasamee, A. & Bovornkitti, S. - Melioidosis: review and update. Rev. infect. Dis., 11: 413-425, 1989.
  • Lowe, P.; Engler, C. & Norton, R. - Comparison of automated and nonautomated system for identification of Burkholderia pseudomallei. J. clin. Microbiol., 40: 4625-4627, 2002.
  • Thomas, A.D. - Evaluation of the API 20E and Microbact 24E systems for the identification of Pseudomonas pseudomallei. Vet. Microbiol., 8: 611-615, 1983.
  • Wuthiekanun, V.; Dance, D.; Chaowagul, W. et al. - Blood culture techniques for the diagnosis of melioidosis. Europ. J. clin. Microbiol. infect. Dis., 9: 654-658, 1990.
  • Wuthiekanun, V.; Dance, D. A.; Wattanagoon, Y. et al. - The use of selective media for the isolation of Pseudomonas pseudomallei in clinical practice. J. med. Microbiol., 33: 121126, 1990.
  • LITFL | Medical Specialty | Infectious Disease | Melioidosis a disease of surprises by Mike Cadogan.
  • Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev. 2005;18 (2):383-416.

Abstract Views: 295

PDF Views: 1




  • Melioidosis:A Great Mimicker

Abstract Views: 295  |  PDF Views: 1

Authors

S. Bhavsar
Internal Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
A. Gupta
Family Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India

Abstract


Melioidosis is an infectious disease of humans and animals, caused by Burkholderia pseudomallei, a gram-negative soil bacterium. It is a disease of tropical climates with reports from North east and South India. It has also been listed as potential bioterrorism weapon. The bacterium causing melioidosis is found in contaminated water and soil. It spreads to humans through inhalation or inoculation.

With clinical presentations ranging from asymptomatic infection to full blown sepsis syndrome with very high mortality rate, early diagnosis and prompt treatment is important to reduce mortality.

Melioidosis is under reported in India, as it needs a high index of suspicion along with the isolation and identification of B. pseudomallei from blood and secretions.


References