The Indian Practitioner

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Ayurvedic Dravyaguna (Pharmacological) Correlates with Biological Plausibility for Antidiabetic activity of Eujenia jambolana Linn


Affiliations
1 KHS-MRC, Mumbai and Ph D Scholar. The Centre for Ayurveda Biology and Holistic Nutrition, The University of Trans-disciplinary Health Sciences and Technology TDU, Bengaluru, India
2 Div of Endocrinology and Metabolic disorder, KHS-MRC, Mumbai, India
3 The Centre for Ayurveda Biology and Holistic Nutrition, The University of Trans-disciplinary Health Sciences and Technology, TDU Bengaluru, India
4 Clinical Research and Integrative Medicine, KHS-MRC, Mumbai, India
5 KHS-MRC, Mumbai and Emeritus Professor, The University of Trans-disciplinary Health Sciences and Technology, India
     

   Subscribe/Renew Journal


Eujenia jambolana Linn (Jambu / Black plum; EjL) was found to be a frequently used medicinal plant in our earlier study of Marketed Ayurvedic Antidiabetic Formulations. Ayurvedic dravyaguna rationale and Biological Plausibility (BP) of EjL for anti-diabetic activity are currently reviewed in view of developing a new drug candidate for type 2 diabetes mellitus using Reverse Pharmacology. Classical and emerging Ayurvedic literature as well as modern pharmacological literature of EjL were reviewed here for Ayurvedic properties and biological plausibility foranti-diabetic potentials.

Keywords

Indian Medicinal Plants, Dravyaguna Rationale, Biological Plausibility, Diabetes, Ayurvedic Pharmacoepidemiology, Jambu, Eugenia jambolana.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Raut A A. Integrative endeavor for renaissance in Ayurveda. J Ayurveda Integr Med. 2011; 2(1): 5–8.

  • Vaidya, RA. Vaidya ADB, Patwardhan B, Tillu G, Rao Y. Ayurvedic Pharmacoepidemiology: A proposed New Descipline. JAPI.2003;51:528

  • Vaidya RA. Observational Therapeutics: Scope, Challenges, and organizations. Journal of Ayurveda & Integrative Medicine.2011;2: 165-169.

  • Vaidya ADB. Reverse Pharmacology Correlates of Ayurvedic Drug Action. Ramnath Chopra Award Oration. Ind J Pharmacol.2006; 38: 311-315

  • Patwardhan B. AyuGenomics–Integration for customized medicine. Indian J. Nat. Prod. Resour.2003; 19: 16–23

  • Padma Venkat. Reverse Pharmacognosy: A novel strategy to standardize ISM drugs.https://www.yumpu.com/en/document/view/35594143/reverse-pharmacognosy-a-novel-strategy-to-standardize-crism

  • Vaidya ADB. Nutraceuticals, Naturals and Nutritionals-A Discovery Path from AyurvedaNuffood. 2013

  • https://www.cdac.in/index.aspx?id=hi_dss_ayusoft_n 9. Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008 Nov;4(11):682-90. doi: 10.1038/nc hembio.118.

  • Satyavati GV, Dwarakanath C, Tripathi SN. Experimental studies on the hypocholesterolemic effect of Commiphoramukul Engl. (Guggul). 1969. Indian J Med Res. 2013 Feb;137(2):14 p following p403

  • Nabar N, Vaidya R, Narayana DB, Raut A, Shah S, Patwardhan B,et al. Marketed Ayurvedic antidiabetic formulations: Labelling, drug Information and branding. The Indian Pract 2013; 66:631‑41.

  • Gajarmal AA, Rath SK. Antidiabetic Activity of IME-9, Research Formula By CCRAS - A Review. Journal of Drug Research 2016; 5(2): 41-58

  • Mayaram Sunderji Vaidya

  • Vaidya AB, Antarkar DS, Joshi B.S Traditional Remedies for diabetes Mellitus: Trails, Trials and Trilateral Quest. Diabetes Bulletin 1989; 186-191

  • GogteVM. Ayurvedic Pharmacology and Therapeutic Uses of Medicinal Plants (Dravyagunavidnyan). Mumbai: Bhavan’s SPARC; 2000.

  • Acharya JT. Editor of ChakrapaniTika by Chakradata of Charaka Samhita, Chaukhambha Sanskrit Sansthan, Varanasi, 5th Ed,2001;211-16 and 444-50(Charaknidan 4 & Charakchikitsa 6)

  • Vaidya ADB, Nabar NS, Vaidya RA. Current Status of Indigenous Drugs and Alternative Medicine in the Management of Diabetes Mellitus. Revised chapter 45 in Volume I of RSSDI Textbook of Diabetes. ED by Tripathy BB, Chandalia HB and team. 3rd Ed 2014 .

  • Terry, Luthar et al. Smoking and Health: Report of the advisory committee to Surgeon General of the United States. U-23 Department of Health,Education and welfare. Public Health Service. Publicationno 1103.1964 (https : // profiles .nlm .nih. gov/ps /retrieve /Resource Metadata /NNBBMQ).

  • Fedak K M, BernalA, Capshaw Z A, and Gross S. Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology. Emerg Themes Epidemiol. 2015; 12: 14.

  • Gamalielsson J., Nilsson P., Olsson B. A GO-Based Method for Assessing the Biological Plausibility of Regulatory Hypotheses. In: Alexandrov V.N., van Albada G.D., Sloot P.M.A., Dongarra J. (eds) Computational Science – ICCS 2006. ICCS 2006. Lecture Notes in Computer Science, vol 3992. Springer, Berlin, Heidelberg.

  • Sasikala SS, Karpakavalli M, Ranjithkumar D, Prakash G, Vanathi P, Mohan S. In-vitro free radical scavenging activity studies of extracts and isolated compounds of Eugenia jambolana Linn. Seeds. World journal of pharmaceutical research. 2016: 5:

  • Jain A, Sharma S, Goyal M, Dubey S, Jain S, et al . Antiinflammatory activity of Syzygium Cumini leaves International Journal of Phytomedicine 2010; 2: 124-126

  • Ahmed F, Chandra JNNS ,Timmaiah NV. An In Vitro Study on the inhibitory Activities of Eugenia jambolana Seeds Against Carbohydrate Hydrolyzing Enzymes. J Young Pharm. 2009;1: 317-321

  • Sharma SB, Tanwar RS, Nasir A, Prabhu KM. Antihyperlipidemic effect of active principle isolated from seed of Eugenia jambolana on alloxan-induced diabetic rabbits. J Med Food. 2011;14(4):353-9.

  • Bilal R, Zakaria M, Usman A, Zia A. Comparison of simvastatin with Eugenia Jambolana fruit pulp in their effects on Alanine Transferase, Aspartate Aminotransferase and Creatinine Phosphokinase levels of hyperlipidaemic rats. J Pak Med Assoc. Vol. 2011; 61(12):1190-1194

  • Franca LM, Coêlho CFF, Freitas LNC, SouzaILS et al. Syzygium cumini Leaf Extract Reverts Hypertriglyceridemia via Down regulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats. Oxidative Medicine and Cellular Longevity.2019, Article ID 9417498

  • Shukla SK, Sharma SB, Singh UR, Ahmad S, Maheshwari A, Misro M, Dwivedi S. Eugenia jambolana pre treatment prevents isoproterenol-induced myocardial damage in rats: evidence from biochemical, molecular, and histopathological studies. J Med Food. 2014 Feb; 17(2):244-53.

  • Behera S R, Sekkizhar M, Sarath Babu K. Nephro-protective Effect of Aqueous Extract of Syzygium cumini Seed on Streptozotocin Induced Diabetes in Rats Int. J. Chem. & Life Sci. 2014;3 : 1285-1288

  • Ribeiro RM, NetoVFP,Ribeiro KS, Vieira DA, et al. Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats Evidence-Based Complementary and Alternative Medicine. 2014, Article ID 605452

  • Tanwar RS, Sharma SB, Prabhu KM. In vivo assessment of antidiabetic and antioxidative activity of natural phytochemical isolated from fruit-pulp of Eugenia jambolana in streptozotocin-induced diabetic rats. Redox Rep. 2017; 22(6):301-307.

  • Rehman AA, Riaz A, Asghar MA, Raza MR, Shadab Ahmed S, Khan K. In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits. BMC Complementary and Alternative Medicine.2019; 19:236

  • Xu J, Liu T, Li Y, Liu W, Ding Z, Ma H, et al. Jamun (Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High-Fat-Diet-Fed Mice. MolNutr Food Res. 2019;63(9):e1801307.

  • Chaudhary A, Bag S, Banerjee P,Chatterjee J. Wound healing efficacy of Jamun honey in diabetic mice model through re epithelialization, collagen deposition and angiogenesis. Journal of Traditional and Complementary Medicine, 2019. https://doi.org/10.1016/j.jtcme.2019.10.002

  • Bijauliya RK, Alok S, Singh M and Mishra SB: Morphology, Phytochemistry and Pharmacology of Syzygium Cumini (Linn.) - An Overview. Int J Pharm Sci Res 2017; 8(6): 236071.doi: 10.13040/IJPSR.0975-8232.8(6).2360-71

  • Chagas VT, França LM, Malik S, Antonio Marcus de Andrade Paes. Syzygium cumini (L.) skeels: a prominent source of bioactive molecules against cardiometabolic diseases. Front Pharmacol 2015; 6: 259

  • Baliga MS, Harshith P. Bhat D, Bantwal RV Baligab,Wilson R, Palatty PL. Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam.(black plum): A review. Food Research International.2011; 44 : 1776–1789

  • Sowjanya KM, Swathi J, Narendra K, Krishna Satya. A review on phytochemical constituents and bioassay of Syzygium cumini International journal of natural product science 2013; 3(2): 1-11

  • Ramya S. K Neethirajan, Jayakumararaj R. Profile of bioactive compounds in Syzygium cumini – a review. Journal of Pharmacy Research 2012,5(8),4548-4553

  • Nighantu Ratnakar. Part 1, edited by Navre KR,notes of Panashikar VL and Soman KV. Choukhambha Sanskrit pratishan. Delhi.1st Ed,2011:87-88

  • Helmstadter A. Syzygium cumini (L.) SKEELS (Myrtaceae) against diabetes –125 years of research. Pharmazie 2008; 63: 91–101

  • Govind Das. Bhaishajya Ratnawali. Ed by R.D. Shashtri., Hindi Commentary. Choukhambha Prakashan, 18th Revised Ed, Varanasai .2007; 37: 719-742

  • BhattA. Phytopharmaceuticals: A new drug class regulated in India. Perspect Clin Res.2016;7:59–61.


Abstract Views: 234

PDF Views: 0




  • Ayurvedic Dravyaguna (Pharmacological) Correlates with Biological Plausibility for Antidiabetic activity of Eujenia jambolana Linn

Abstract Views: 234  |  PDF Views: 0

Authors

N. S. Nabar
KHS-MRC, Mumbai and Ph D Scholar. The Centre for Ayurveda Biology and Holistic Nutrition, The University of Trans-disciplinary Health Sciences and Technology TDU, Bengaluru, India
R. A. Vaidya
Div of Endocrinology and Metabolic disorder, KHS-MRC, Mumbai, India
C. N. Vishnuprasad
The Centre for Ayurveda Biology and Holistic Nutrition, The University of Trans-disciplinary Health Sciences and Technology, TDU Bengaluru, India
A. A. Raut
Clinical Research and Integrative Medicine, KHS-MRC, Mumbai, India
A. D. B. Vaidya
KHS-MRC, Mumbai and Emeritus Professor, The University of Trans-disciplinary Health Sciences and Technology, India

Abstract


Eujenia jambolana Linn (Jambu / Black plum; EjL) was found to be a frequently used medicinal plant in our earlier study of Marketed Ayurvedic Antidiabetic Formulations. Ayurvedic dravyaguna rationale and Biological Plausibility (BP) of EjL for anti-diabetic activity are currently reviewed in view of developing a new drug candidate for type 2 diabetes mellitus using Reverse Pharmacology. Classical and emerging Ayurvedic literature as well as modern pharmacological literature of EjL were reviewed here for Ayurvedic properties and biological plausibility foranti-diabetic potentials.

Keywords


Indian Medicinal Plants, Dravyaguna Rationale, Biological Plausibility, Diabetes, Ayurvedic Pharmacoepidemiology, Jambu, Eugenia jambolana.

References