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COVID-19 Treatment:Current and Emerging Options


Affiliations
1 Aristo Pharmaceuticals Private Limited, Mumbai, India
     

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Coronavirus disease 2019 (COVID-19) which is caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has posed a clinical threat to the global population. Its resemblance to SARS-CoV along with several other bat coronaviruses have been established through genome sequencing- related studies. The disease spreads by human-to-human transmission via droplets or direct contact and presents flu-like symptoms. It can have poor prognosis in high-risk individuals having co-morbid conditions. Though currently, no proven effective therapies for SARS-CoV-2 exist, many therapeutic agents are being repurposed to treat patients with COVID-19. The key aspect determining the prognosis of COVID-19 patients is the early accurate diagnosis followed by the management of acute respiratory failure and hemodynamic instability in moderate-severe cases. COVID-19 presents an unparalleled chal-lenge to identify potential therapeutic agents for prophylaxis and treatment. There is an explicit and urgent need to explore all the possible prophylactic and therapeutic strategies to curb the spread of SARS-CoV-2. A large number of clinical trials have been launched to investigate potential therapies for COVID-19 and to provide the clinicians ac-curate evidence regarding effective medical treatments for this infection. The current review closely examines the drugs that are being explored and also those drugs which have a potential for consideration. Though the therapeutic options have not undergone extensive pre-clinical and clinical testing, each has a known merit and identified mecha-nism against viral infection. The review is based on currently available information and as new evidence emerges, reappraisal of therapies is anticipated.

Keywords

COVID-19, Management, SARS-CoV-2, Potential Therapies, Evidence.
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  • COVID-19 Treatment:Current and Emerging Options

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Authors

Manish Maladkar
Aristo Pharmaceuticals Private Limited, Mumbai, India
Chitra Tekchandani
Aristo Pharmaceuticals Private Limited, Mumbai, India
Akshata Karchodi
Aristo Pharmaceuticals Private Limited, Mumbai, India

Abstract


Coronavirus disease 2019 (COVID-19) which is caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has posed a clinical threat to the global population. Its resemblance to SARS-CoV along with several other bat coronaviruses have been established through genome sequencing- related studies. The disease spreads by human-to-human transmission via droplets or direct contact and presents flu-like symptoms. It can have poor prognosis in high-risk individuals having co-morbid conditions. Though currently, no proven effective therapies for SARS-CoV-2 exist, many therapeutic agents are being repurposed to treat patients with COVID-19. The key aspect determining the prognosis of COVID-19 patients is the early accurate diagnosis followed by the management of acute respiratory failure and hemodynamic instability in moderate-severe cases. COVID-19 presents an unparalleled chal-lenge to identify potential therapeutic agents for prophylaxis and treatment. There is an explicit and urgent need to explore all the possible prophylactic and therapeutic strategies to curb the spread of SARS-CoV-2. A large number of clinical trials have been launched to investigate potential therapies for COVID-19 and to provide the clinicians ac-curate evidence regarding effective medical treatments for this infection. The current review closely examines the drugs that are being explored and also those drugs which have a potential for consideration. Though the therapeutic options have not undergone extensive pre-clinical and clinical testing, each has a known merit and identified mecha-nism against viral infection. The review is based on currently available information and as new evidence emerges, reappraisal of therapies is anticipated.

Keywords


COVID-19, Management, SARS-CoV-2, Potential Therapies, Evidence.

References