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Hypokalemic Periodic Paralysis and Renal tubular Acidosis as Presenting Manifestation of Primary Sjogren’s Syndrome - A Case Report


Affiliations
1 department of neurology, Pacific Medical College and Hospital, Udaipur, Rajasthan - 313011, India
2 department of internal medicine, Pacific Medical College and Hospital, Udaipur, Rajasthan - 313011, India
3 department of neurology Pacific Medical College and Hospital, Udaipur, Rajasthan - 313011, India
     

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Among wide list of differentials of periodic paralysis, hypokalemia is an important cause. However hypokalemia with respiratory failure as sole presenting feature of Sjogren’s syndrome (SS) is rarely reported. We report a case of recur-rent hypokalemic paralysis which presented with life threatening respiratory failure in second episode, hypokalemia was found due to distal renal tubular acidosis and on further investigation diagnosis of primary SS was made. In this article we emphasize need for detailed work-up of a case of recurrent hypokalemic periodic paralysis in order to iden-tify the underlying etiology and do timely management in order to avoid future recurrence.

Keywords

Hypokalemic Periodic Paralysis, Sjogren’s Syndrome, Quadriparesis.
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  • Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL. Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren’s syndrome and distal renal tubular acidosis.J Am Soc Nephrol. 1992;3:264–71.

  • Soy M, Pamuk ON, Gerenli M, Celik Y. A primary Sjogren’s syndrome patient with distal renal tubular acidosis, who presented with symptoms of hypokalemic periodic paralysis. Rheumatol Int 2005;26:86 – 9.

  • Bossini N, Savoldi S, Franceschini F, Mombelloni S, Baronio M, Cavazzana I,et al.Clinical and morphological features of kidney involvement in primary Sjögren’s syndrome. Nephrol Dial Transplant. 2001;16:2328–36.

  • Yilmaz H, Kaya M, Özbek M, ÜUreten K, Safa Yildirim I. Hypokalemic periodic paralysis in Sjogren’s syndrome secondary to distal renal tubular acidosis. Rheumatol Int 2013;33:1879-82.

  • Khandelwal D, Bhattacharya S, Khadgawat R, Kaur S, Tandon N, Ammini AC. Hypokalemic paralysis as a presenting manifestation of primary Sjögren’s syndrome : A0 report of two cases. Indian J Endocrinol Metab 2012;16:853-5.

  • M Goroshi, S Khare, T Jamale,NS Shah. Primary Sjogren’s syndrome presenting as hypokalemic paralysis: A case series: J Postgrad Med. 2017;63(2):128–131.

  • FoxRI.Sjögren’ssyndrome. Lancet2005;366:321-31.

  • Maripuri S, Grande JP, Osborn TG, Fervenza FC, Matteson EL, Donadio JV, et al.Renal involvement in primary Sjögren’s syndrome: A clinicopathologic study. Clin J Am Soc Nephrol 2009;4:1423-31.

  • Chen LH, Hsu PN, Chen MY, Lee KL, Hsieh SC, Yu CL. Renal tubular acidosis in patients with primary Sjogren’s syndrome. JRheumatol2007;21:13–9.

  • Both T, Hoorn EJ, Zietse R, van Laar JA, Dalm VA, Brkic Z, et al.Prevalence of distal renal tubular acidosis in primary Sjögren’s syndrome. Rheumatology (Oxford) 2015;54:933-9.

  • Fraer M. A mask and many faces: hypokalemic periodic paralysis. South Med J 2008;101:887.

  • Rao N, John M, Thomas N, Rajaratnam S, Seshadri MS. Aetiological, clinical and metabolic profile of hypokalaemic periodic paralysis in adults: a single-centre experience. Natl Med J India 2006;19:246-9.


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  • Hypokalemic Periodic Paralysis and Renal tubular Acidosis as Presenting Manifestation of Primary Sjogren’s Syndrome - A Case Report

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Authors

Saurabh Gupta
department of neurology, Pacific Medical College and Hospital, Udaipur, Rajasthan - 313011, India
Shikha Gupta
department of internal medicine, Pacific Medical College and Hospital, Udaipur, Rajasthan - 313011, India
Naushad Ravjani
department of neurology Pacific Medical College and Hospital, Udaipur, Rajasthan - 313011, India

Abstract


Among wide list of differentials of periodic paralysis, hypokalemia is an important cause. However hypokalemia with respiratory failure as sole presenting feature of Sjogren’s syndrome (SS) is rarely reported. We report a case of recur-rent hypokalemic paralysis which presented with life threatening respiratory failure in second episode, hypokalemia was found due to distal renal tubular acidosis and on further investigation diagnosis of primary SS was made. In this article we emphasize need for detailed work-up of a case of recurrent hypokalemic periodic paralysis in order to iden-tify the underlying etiology and do timely management in order to avoid future recurrence.

Keywords


Hypokalemic Periodic Paralysis, Sjogren’s Syndrome, Quadriparesis.

References