A Review of the Role of Silodosin as Medical Expulsive Therapy for Ureteral Stones

Urolithiasis is a chronic human condition that has immense public health importance and it poses a tremendous economic burden on our society. Medical expulsive therapy (MET) for the treatment of ureteral stones has emerged as a cost-effective approach. In the last few years, a number of drugs have been introduced and used successfully as MET for the expulsion of small, uncomplicated ureteral calculi. Using a selective α-adrenoceptor blocker for MET has emerged as an effective treatment approach and is widely used for ureteral stones. Silodosin, a selective α-blocker, has a higher selectivity for the α1A receptor as compared to other agents in the class. The objective of this review is to determine the efficacy and safety of Silodosin in MET as compared to placebo and Tamsulosin.