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Extranodal Histiocytic Sarcoma Rectum: A Case Report


Affiliations
1 Department of Gastroenterology, IGMC- Shimla, Himachal Pradesh, India
2 Department of Surgery, IGMC - Shimla, India
     

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Histiocytic sarcoma (HS) is an exceedingly rare but aggressive hematopoietic tumor, showing morphologic and immunophenotypic features of mature tissue histiocytes. Diagnosis of HS is based on histological and immunohistochemical evidence of histiocytic differentiation supported by an extensive immunophenotypic analysis that excludes other large cell malignancies in the differential diagnosis. Search of world literature revealed only three previous reports of extranodal histiocytic sarcoma (ENHS) involving rectum specifically. We report a case of ENHS of rectum in a 65 year old man presenting with hematochezia. Radiological findings were indicative of polypoidal soft tissue mass lesion in rectum. Histopathology and immunohistochemical studies of the resected specimen confirmed the uncommon diagnosis ENHS.

Keywords

Histiocytic Sarcoma, Extranodal Histiocytic Sarcoma, Magnetic Resonance Imaging.
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  • Takahashi E, Nakamura S. Histiocytic Sarcoma : An Updated Literature Review Based on the 2008 WHO Classification. J Clin Exp Hematop. 2013; 53(1): 1-8.

  • Skala S L, Lucas D R, Dewar R. Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis. Arch Pathol Lab Med. 2018;142:1322– 1329

  • Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: Clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol 2004; 28:1133 44.

  • Vos JA, Abbondanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS. Histiocytic sarcoma: A study of five cases including the histiocyte marker CD163. Mod Pathol 2005; 18:693 704.

  • Park MI, Song KS, Kang DY. Histiocytic sarcoma of rectum – A case report. Korean J Pathol 2006; 40:156 9.

  • Jiang QM, Zhou WW, Song R, Ye XZ, Li J. [Histiocytic sarcoma: A clinicopathologic study of 4 cases]. Zhonghua Xue Ye Xue Za Zhi 2012; 33:751 5.

  • Mitra S, Jhunjhunwala A, Mukherjee P. Extranodal histiocytic sarcoma mimicking colorectal lymphoma: Case report and review of literature. Indian J Pathol Microbiol 2019; 62:467-9.

  • Swerdlow SH, Campo E, Harris NL, et al. (eds). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon, France: International Agency for Research on Cancer; 2017.


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  • Extranodal Histiocytic Sarcoma Rectum: A Case Report

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Authors

Vishal Bodh
Department of Gastroenterology, IGMC- Shimla, Himachal Pradesh, India
Rajesh Sharma
Department of Surgery, IGMC - Shimla, India
Brij Sharma
Department of Surgery, IGMC - Shimla, India
Rajesh Kumar
Department of Surgery, IGMC - Shimla, India
Puneet Mahajan
Department of Surgery, IGMC - Shimla, India

Abstract


Histiocytic sarcoma (HS) is an exceedingly rare but aggressive hematopoietic tumor, showing morphologic and immunophenotypic features of mature tissue histiocytes. Diagnosis of HS is based on histological and immunohistochemical evidence of histiocytic differentiation supported by an extensive immunophenotypic analysis that excludes other large cell malignancies in the differential diagnosis. Search of world literature revealed only three previous reports of extranodal histiocytic sarcoma (ENHS) involving rectum specifically. We report a case of ENHS of rectum in a 65 year old man presenting with hematochezia. Radiological findings were indicative of polypoidal soft tissue mass lesion in rectum. Histopathology and immunohistochemical studies of the resected specimen confirmed the uncommon diagnosis ENHS.

Keywords


Histiocytic Sarcoma, Extranodal Histiocytic Sarcoma, Magnetic Resonance Imaging.

References