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Efficacy of Continuous Positive Airway Pressure (CPAP) in Patients with Obstructive Sleep Apnea (OSA): A Real-World Study


Affiliations
1 ASRA Centre for Chest Diseases, Allergy and Sleep Disorders, New Delhi, India
2 ASRA Centre for Sleep, New Delhi, India
3 Medstar Hospital, Washington D.C., United States
     

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Background: Sleep being an essential biological function, has a significant role. The basic structure of sleep consists of non-rapid eye movement (NREM) and rapid eye movement (REM). Obstructive sleep apnea-hypopnea syndrome (OSAHS) is the commonest of sleep-related breathing disorders, which is a chronic disorder characterized by the presence of partial or complete blockage of the upper airway causing reduced (hypopnea) or absent (apnea) airflow during sleep. Continuous positive airway pressure (CPAP) therapy reduces OSA severity, improves both daytime and nocturnal symptoms in particular excessive daytime sleepiness and fatigue. Objective: Assessment of AHI, Arousal Index, and sleep pattern improvement (N1, N2, N3, and R duration), blood pressure pre and post CPAP therapy and compliance of patients to CPAP therapy over a period of ≥6 months Methodology: A total 107 polysomnography (PSG) reports of patients who visited the sleep centre from March 2019 to March 2020 were included for the analysis. Results: Our study reported a significant decrease (p<0.0001) in AHI, Arousal Index, and blood pressure post CPAP therapy in the overall population, both the genders and in all age groups. There was a significant increase in N3, and R (p<0.05) post CPAP therapy in most of the patients, whereas there was a marginal decrease in N1 and N2 post CPAP therapy. Conclusion: Our results from the real-life clinical setting confirms that CPAP is effective at decreasing AHI, Arousal Index, blood pressure, and adherence to treatment with CPAP reported increased sleep efficiency and improvement in both nocturnal and diurnal symptoms in Indian patients with moderate to severe OSA.

Keywords

Continuous Positive Airway Pressure, Obstructive Sleep Apnea, CPAP, OSA, Real-world.
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  • Efficacy of Continuous Positive Airway Pressure (CPAP) in Patients with Obstructive Sleep Apnea (OSA): A Real-World Study

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Authors

Animesh Arya
ASRA Centre for Chest Diseases, Allergy and Sleep Disorders, New Delhi, India
Seema Arya
ASRA Centre for Sleep, New Delhi, India
Radhika Arya
Medstar Hospital, Washington D.C., United States

Abstract


Background: Sleep being an essential biological function, has a significant role. The basic structure of sleep consists of non-rapid eye movement (NREM) and rapid eye movement (REM). Obstructive sleep apnea-hypopnea syndrome (OSAHS) is the commonest of sleep-related breathing disorders, which is a chronic disorder characterized by the presence of partial or complete blockage of the upper airway causing reduced (hypopnea) or absent (apnea) airflow during sleep. Continuous positive airway pressure (CPAP) therapy reduces OSA severity, improves both daytime and nocturnal symptoms in particular excessive daytime sleepiness and fatigue. Objective: Assessment of AHI, Arousal Index, and sleep pattern improvement (N1, N2, N3, and R duration), blood pressure pre and post CPAP therapy and compliance of patients to CPAP therapy over a period of ≥6 months Methodology: A total 107 polysomnography (PSG) reports of patients who visited the sleep centre from March 2019 to March 2020 were included for the analysis. Results: Our study reported a significant decrease (p<0.0001) in AHI, Arousal Index, and blood pressure post CPAP therapy in the overall population, both the genders and in all age groups. There was a significant increase in N3, and R (p<0.05) post CPAP therapy in most of the patients, whereas there was a marginal decrease in N1 and N2 post CPAP therapy. Conclusion: Our results from the real-life clinical setting confirms that CPAP is effective at decreasing AHI, Arousal Index, blood pressure, and adherence to treatment with CPAP reported increased sleep efficiency and improvement in both nocturnal and diurnal symptoms in Indian patients with moderate to severe OSA.

Keywords


Continuous Positive Airway Pressure, Obstructive Sleep Apnea, CPAP, OSA, Real-world.

References