Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

COVID Vaccines in India – A Medical Milestone: Current and Future Prospects


Affiliations
1 Consultant Family Medicine and Holistic Health, Dr Varsha’s Health Solutions, Mumbai, India
     

   Subscribe/Renew Journal


At the start of 2021, two COVID vaccines have received approval for emergency use in India. The review of study data available on the safety and efficacy of these vaccines, and understanding their technological development along with rational of their approval, can help in achievement of a more effective vaccination drive. It is important at this stage that apprehensions and concerns on these vaccines are addressed scientifically in a balanced manner to improve vaccination coverage and success. A peek into what the near future holds also points towards India emerging as an effective global player in vaccines.

Keywords

COVID, Vaccine, Adenoviral Vector, Inactivated, Immunogenicity, Safety.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ministry of Health and Family Welfare [Internet]: Press Statement by the Drugs Controller General of India (DCGI) on Restricted Emergency approval of COVID-19 virus vaccine. Posted: 03 JAN 2021 11:23AM by PIB Delhi. [cited 2021 Jan 5]. Available from: https://pib.gov.in/PressReleseDetail.aspx?PRID=1685761
  • Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij Rammerstorfer S et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomized controlled trial. Lancet 2020 Aug 15;396:467–78.
  • Ramasamy MN, Minassian AM, Ewer KJ, Flaxman AL, Folegatti PM, Owens DR et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a primeboost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. Lancet 2020;396:1979–93.
  • Voysey M, Clemen SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK et al. Safety and efficacy of the ChAdOx1nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomized controlled trials in Brazil, South Africa, and the UK. Lancet [internet]. Published online 2020 December 8; S0140-6736(20)32661-1. [cited 2021 Jan 5]. Available from: https://www.thelancet.com/journals/lancet/ article/PIIS0140-6736(20)32661-1/fulltext
  • A Phase 2/3 Observer-Blind Randomized Controlled Study to determine the Safety and Immunogenicity of COVISHIELD (COVID-19 Vaccine) in healthy Indian adults. CTRI/2020/08/02170. [cited 2021 Jan 5]. Available from: http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=46186&E ncHid=&userName=covid-19%20vaccine
  • Ella R, Vadrevu KM, Jogdand H, Prasad S, Reddy S, Sarangi V et al. A Phase 1: Safety and Immunogenicity Trial of an Inactivated SARS-CoV-2 Vaccine-BBV152. 2020 December 15. Pre-Print. [cited 2021 Jan 6]. Available from: https://www.medrxiv.org/content/10.1101/2020.12.11.20210419v1
  • Ella R, Reddy S, Jogdand H, Sarangi V, Ganneru B, Prasad S et al. Safety and immunogenicity clinical trial of an inactivated SARS-CoV-2 vaccine, BBV152 (a phase 2, double-blind, randomized controlled trial) and the persistence of immune responses from a phase 1 follow-up report.2020 December 22. Pre-Print. [cited 2021 Jan 6]. Available from: https://www.medrxiv.org/content/10.1101/2020.12.21.20248643v1.full.pdf
  • Das S. Covid-19 vaccine: Bharat Biotech completes recruitment for phase 3 trials [internet]. Business Standard. 2021 January 7. [cited 2021 Jan 8]. Available from: https://www.business-standard.com/article/current-affairs/covid-19-vaccine-bharat-biotech-completes-recruitment-for-phase-3-trials 121010701171_1.html
  • CDSCO [internet]. New Drugs and Clinical Trials Rules 2019. Part II, Sec 3(i) Accelerated Approval Process Page 186. [cited 2021 Jan 9]. Available from: https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/NewDrugs_CTRules_2019.pdf
  • Ahlén G, Frelin L, Nikouyan N, Weber F, Höglund U, Larsson O et al for the OPENCORONA Consortium. 2020. The SARSCoV 2 N protein is a good component in a vaccine. J Virol [Internet] 94:e01279-20. [cited 2021, Jan 9]. Available from: https://jvi.asm.org/content/94/18/e01279-20
  • Ghosh P. Bharat Biotech vaccine may have some advantage [internet]. Hindustan Times. 2021 January 03. [cited 2021 Jan 9]. Available from: https://www.hindustantimes.com/indianews/bharat-biotech-vaccine-may-have-some-advantages-icmr-chief-on-covaxin-mutant-strain/story-wPtilHX022GmdfxF4tSxaM.html
  • Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockart S et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med Dec 2020; 383:2603-15.
  • Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. NEJM [internet]. Published online 2021 Dec 30. [cited 2021 Jan 5]. Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa2035389
  • Sputnik vaccine [internet]. Sputnik V– Second Interim Analysis of clinical trial data. Press Release. 2020 Nov 24. [cited 2021 Jan 9]. Available from: https://sputnikvaccine.com/newsroom/pressreleases/second-interim-analysis-ofclinical trial-data-showed-a-91-4-efficacy-for-the-sputnik-vvaccine on-d/
  • Reuters [internet]. China gives its first COVID-19 vaccine approval to Sinopharm. Press Release. 2020 Dec 31. [cited 2021 Jan 5]. Available from: https://www.reuters.com/article/us-health-coronavirus-vaccine-china/china-gives-its-first-covid-19-vaccine-approval-to-sinopharm-idUSKBN29505P
  • Swell HF, Agius RM, Kendrick D. Covid-19 vaccines: delivering protective immunity. BMJ [internet]. 2020;371:m4838. [cited 2021 Jan 9]. Available on: https://www.bmj.com/content/371/bmj.m4838
  • Rawat K. Kumari P, Saha L. COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies. Eur J Pharmacol. 2021 Feb 5;892:73751.

Abstract Views: 256

PDF Views: 1




  • COVID Vaccines in India – A Medical Milestone: Current and Future Prospects

Abstract Views: 256  |  PDF Views: 1

Authors

Varsha Narayanan
Consultant Family Medicine and Holistic Health, Dr Varsha’s Health Solutions, Mumbai, India

Abstract


At the start of 2021, two COVID vaccines have received approval for emergency use in India. The review of study data available on the safety and efficacy of these vaccines, and understanding their technological development along with rational of their approval, can help in achievement of a more effective vaccination drive. It is important at this stage that apprehensions and concerns on these vaccines are addressed scientifically in a balanced manner to improve vaccination coverage and success. A peek into what the near future holds also points towards India emerging as an effective global player in vaccines.

Keywords


COVID, Vaccine, Adenoviral Vector, Inactivated, Immunogenicity, Safety.

References