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Colorectal Cancers: Recent Advancements in Diagnostic and Preventive Strategies of Hereditary Tumours (Lynch Syndrome)
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Lynch syndrome, is one of the most common hereditary colorectal cancer predisposition conditions, is characterised by an increased risk to a spectrum of cancers, primarily colorectal and endometrial cancers. We highlight the urgent need to diagnose, explain diagnostic methodologies and several cancer risks reducing interventions in these patients and their rela-tives. We highlight the role of aspirin as a potent chemo preventive agent in Lynch syndrome patients and discuss patient groups where the dose and duration of the intervention may require personalisation. With new genetic technologies on the horizon, early detection of these patients coupled with targeted chemo preventive intervention could potentially lead to the reduction of the cancer burden in India.
Keywords
Lynch syndrome, colorectal cancer, aspirin, chemoprevention
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