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Obesity, Obstructive Sleep Apnoea, and Metabolic Syndrome: The Fatal Association


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1 Professor of Pulmonary Medicine, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India
     

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Obesity is the most common health risk for individuals of all age groups across the globe. Obstructive sleep apnoea (OSA) is now recognized as a major health problem in developed countries. The prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is associated with metabolic syndrome. Pathophysiological triggers of intermittent hypoxia and sleep fragmentation in OSA is responsible for cardiometabolic dysfunction. The potential mechanisms of OSA-obesity-metabolic syndrome interaction involve sympathetic activation, oxidative stress, inflammation and neurohumoral changes. In spite of support for an independent role of OSA in the contribution towards metabolic dysfunction, obesity plays a determinant role in initiating both these conditions.

Keywords

obesity, cardiometabolic dysfunction, metabolic syndrome
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  • Obesity, Obstructive Sleep Apnoea, and Metabolic Syndrome: The Fatal Association

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Authors

Ravindran Chetambath
Professor of Pulmonary Medicine, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India

Abstract


Obesity is the most common health risk for individuals of all age groups across the globe. Obstructive sleep apnoea (OSA) is now recognized as a major health problem in developed countries. The prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is associated with metabolic syndrome. Pathophysiological triggers of intermittent hypoxia and sleep fragmentation in OSA is responsible for cardiometabolic dysfunction. The potential mechanisms of OSA-obesity-metabolic syndrome interaction involve sympathetic activation, oxidative stress, inflammation and neurohumoral changes. In spite of support for an independent role of OSA in the contribution towards metabolic dysfunction, obesity plays a determinant role in initiating both these conditions.

Keywords


obesity, cardiometabolic dysfunction, metabolic syndrome

References