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The third wave of COVID-19 due to the Omicron variant has started in India. Being highly infective, there is an exponential increase in the number of daily cases. At this time, urgent steps are needed to minimise community transmission and thereby, protect healthcare workers (HCW) from being infected, which could result in disastrous consequences for the ultimate management of seriously ill patients. Apart from observing Covid appropriate behaviour, we have measures such as vaccines, targeted antivirals and monoclonal antibodies to prevent serious disease, whose efficacy need to be established. Systematic planning, adequate stock of oxygen, essential drugs like steroids and blood thinners will go a long way in tiding over this third wave too.