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Prescription is a written order for medication in clinical practice and serves as communication between the prescriber and pharmacist. Writing of prescription is a scientific technique and skill; every clinician must know the format and steps involved in writing good prescriptions. There are two types of prescriptions but due to availability of readymade formulations, the role of pharmacist is limited to dispensing only. Most of the medicines are only available after producing a prescription, hence called as prescription drugs. But some common medicines are available without prescription known as non-prescription or popularly as over-the-counter drugs. In Indian prescriptions we have seen various shades of religious symbols. Prescribing medicines in extreme ages of pediatrics and geriatrics is another important skill. Similarly, female pregnancy and lactation are also crucial conditions that need special attention of prescribing. Clinicians must be cautious and take special attention while prescribing for hepatic and renal disorders.