The Indian Practitioner

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hydrogel Matrix Diffusion Technology: Development of Controlled Release Formulation Aiming for Enhanced Adherence


Affiliations
1 SERVIER INDIA Private Limited, Bandra Kurla Complex, Bandra (East), Mumbai- 400051, India
     

   Subscribe/Renew Journal


Hydrogels or hydrated matricesare water-based three-dimensional systems with numerous hydrophilic groups. The highly porous hydrogels swell on exposure to water in the gastrointestinal tract creating a mesh-like structure of the polymer cross-links, entrapping the drug particles inside that matrix. Subsequently, the embedded drug particles diffuse through the swollen gel-like layer creating a controlled impediment to drug release. The zones of the dissolved and un-dissolved drug are parted by two sides from the swollen gel region, namely the diffusion front and the erosion front. Drug release can occur by diffusion, erosion, or both. Thus, drug release is modulated by the hydrogel barrier enabling controlled release. This Hydrogel Matrix Diffusion Technology (HMDT) offers dimensional and temporal regulation of drug release patterns. Carbopol polymers also known as smart gels are usually used to manufacture stimuli-responsive (pH or temperature) hydrogels enabling their utilization across therapy areas. Given their several conformable parameters that permit the controlled delivery of various therapeutic agents, hydrogels are exceptional contenders for oral drug delivery. HMDT can help improve adherence by reducing the dosing frequency/pill burden, thereby improving clinical outcomes. This is particularly critical for chronic diseases like diabetes, chronic stable angina, heart failure, hypertension, and several others. There is adequate clinical evidence for example the PROFICIENT study with Ivabradine showing similar clinical effectiveness with a once-daily regimen as multiple-dose regimenswith improved treatment compliance.

Keywords

hydrogel matrix diffusion technology, once-daily regimen, chronic diseases, adherence.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Liechty WB, Kryscio DR, Slaughter BV, Peppas NA. Polymers for drug delivery systems. Annu Rev Chem Biomol Eng. 2010;1:149-73.

  • Vermonden T, Censi R, Hennink WE. Hydrogels for protein delivery. Chem Rev. 2012;112(5):2853–88.

  • Morishita M, Peppas NA. Is the oral route possible for peptide and protein drug delivery? Drug Discov Today. 2006;11(19):905–10.

  • Peppas NA, Wood KM, Blanchette JO. Hydrogels for oral delivery of therapeutic proteins. Expert Opin Biol Ther. 2004;4(6):1–7.

  • Li J, Mooney DJ. Designing hydrogels for controlled drug delivery. Nat Rev Mater. 2016;1(12):16071.

  • Yar M, Shahzad S, Siddiqi SA, Mahmood N, Rauf A, Anwar MS, et al. Triethyl orthoformate mediated a novel crosslinking method for the preparation of hydrogels for tissue engineering applications: characterization and in vitro cytocompatibility analysis. Mater Sci Eng C Mater Biol Appl. 2015;56:154-64.

  • Ullah F, Othman MB, Javed F, Ahmad Z, Md Akil H. Classification, processing and application of hydrogels: A review. Mater Sci Eng C Mater Biol Appl. 2015;57:414-33.

  • Ahmed EM. Hydrogel: Preparation, characterization, and applications: A review. J Adv Res. 2015;6(2):105-21.

  • Samanta HS, Ray SK. Controlled release of tinidazole and theophylline from chitosan based composite hydrogels. Carbohydr Polym. 2014;106:109-20.

  • Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev. 2010;62(1):83- 99.

  • Maderuelo C, Zarzuelo A, Lanao JM. Critical factors in the release of drugs from sustained release hydrophilic matrices. J Control Release. 2011;154(1):2-19.

  • Colombo P. Swelling: Controlled release in hydrogel matrices for oral route. Adv drug delivery.1993;11: 37-57.

  • Nokhodchi A, Raja S, Patel P, Asare-Addo K. The role of oral controlled release matrix tablets in drug delivery systems. Bioimpacts. 2012;2(4):175-87.

  • Vasile C et al. New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers. Molecules. 2020;25:1539

  • Suhail M, Wu PC, Minhas MU. Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation. Pharmaceuticals (Basel). 2020;13(11):399.

  • Ron ES, Bromberg LE. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Adv Drug Deliv Rev. 1998;31(3):197-221.

  • Bettini R, Colombo P, Peppas NA. Solubility Effects on Drug Transport through Ph-Sensitive, Swelling-Controlled Release Systems-Transport of Theophylline and Metoclopramide Monohydrochloride. J Control Release. 1995;37:105–111.

  • Fogueri LR, Singh S. Smart polymers for controlled delivery of proteins and peptides: a review of patents. Recent Pat Drug Deliv Formul. 2009;3(1):40-8.

  • Galaev I. ’Smart’ polymers and what they could do in biotechnology and medicine. Trends Biotechnol. 1999;17:335–340.

  • Taylor NW, Bagley EB. Tailoring closely packed gel–particle systems for use as thickening agents. J Appl Polym Sci. 1977;21:113– 122.

  • EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Silano V, Barat Baviera JM, Bolognesi C, Brüschweiler BJ, Chesson A, Cocconcelli PS, et al. Safety assessment of the active substance polyacrylic acid, sodium salt, cross-linked, for use in active food contact materials. EFSA J. 2018;16(11):e05448.

  • Ruppar TM, Cooper PS, Mehr DR, Delgado JM, Dunbar-Jacob JM. Medication Adherence Interventions Improve Heart Failure Mortality and Readmission Rates: Systematic Review and Meta- Analysis of Controlled Trials. J Am Heart Assoc. 2016;5(6):e002606.

  • Caldeira D, Vaz-Carneiro A, Costa J. The impact of dosing frequency on medication adherence in chronic cardiovascular disease: systematic review and meta-analysis. Rev Port Cardiol. 2014;33(7- 8):431-7.

  • Rodriguez F, Cannon CP, Steg PG, Kumbhani DJ, Goto S, Smith SC, et al; REACH Registry Investigators. Predictors of long-term adherence to evidence-based cardiovascular disease medications in outpatients with stable atherothrombotic disease: findings from the REACH Registry. Clin Cardiol. 2013;36(12):721-7.

  • Kolandaivelu K, Leiden BB, O’Gara PT, Bhatt DL. Non-adherence to cardiovascular medications. Eur Heart J. 2014;35(46):3267-76.

  • Tan J, Wang Y, Liu S, Shi Q, Zhou X, Zhou Y, et al. Long-Acting Metformin Vs. Metformin Immediate Release in Patients With Type 2 Diabetes: A Systematic Review. Front Pharmacol. 2021;12:669814.

  • Kardas P; COMPASS Investigators. Comparison of once daily versus twice daily oral nitrates in stable angina pectoris. Am J Cardiol. 2004;94(2):213-6.

  • Mullasari A; PROFICIENT investigators. Efficacy and Safety of Ivabradine Once-Daily Prolonged-Release versus Twice-Daily Immediate-Release Formulation in Patients with Stable Chronic Heart Failure with Systolic Dysfunction: A Randomized, Double- Blind, Phase 3 Non-Inferiority (PROFICIENT) Study. Cardiol Ther. 2020;9(2):505-521.


Abstract Views: 175

PDF Views: 0




  • Hydrogel Matrix Diffusion Technology: Development of Controlled Release Formulation Aiming for Enhanced Adherence

Abstract Views: 175  |  PDF Views: 0

Authors

Priya Ann Sam
SERVIER INDIA Private Limited, Bandra Kurla Complex, Bandra (East), Mumbai- 400051, India
Poonam Gupta
SERVIER INDIA Private Limited, Bandra Kurla Complex, Bandra (East), Mumbai- 400051, India
Sambhaji Jadhav
SERVIER INDIA Private Limited, Bandra Kurla Complex, Bandra (East), Mumbai- 400051, India

Abstract


Hydrogels or hydrated matricesare water-based three-dimensional systems with numerous hydrophilic groups. The highly porous hydrogels swell on exposure to water in the gastrointestinal tract creating a mesh-like structure of the polymer cross-links, entrapping the drug particles inside that matrix. Subsequently, the embedded drug particles diffuse through the swollen gel-like layer creating a controlled impediment to drug release. The zones of the dissolved and un-dissolved drug are parted by two sides from the swollen gel region, namely the diffusion front and the erosion front. Drug release can occur by diffusion, erosion, or both. Thus, drug release is modulated by the hydrogel barrier enabling controlled release. This Hydrogel Matrix Diffusion Technology (HMDT) offers dimensional and temporal regulation of drug release patterns. Carbopol polymers also known as smart gels are usually used to manufacture stimuli-responsive (pH or temperature) hydrogels enabling their utilization across therapy areas. Given their several conformable parameters that permit the controlled delivery of various therapeutic agents, hydrogels are exceptional contenders for oral drug delivery. HMDT can help improve adherence by reducing the dosing frequency/pill burden, thereby improving clinical outcomes. This is particularly critical for chronic diseases like diabetes, chronic stable angina, heart failure, hypertension, and several others. There is adequate clinical evidence for example the PROFICIENT study with Ivabradine showing similar clinical effectiveness with a once-daily regimen as multiple-dose regimenswith improved treatment compliance.

Keywords


hydrogel matrix diffusion technology, once-daily regimen, chronic diseases, adherence.

References