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Beta Cell Centric Approach in the Management of Diabetes


Affiliations
1 President-Medical & Regulatory Affairs, Dept. of Scientific;, India
2 Deputy General Manager-Medical, Dept. of Scientific, India
3 Assistant General Manager-Medical, Dept. of Scientific;, India
4 Senior Executive-Scientific, Dept. of Scientific, Aristo Pharmaceuticals Private Limited,, India
     

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Type 2 Diabetes (T2DM) is a complex, progressive, chronic metabolic disorder that is mainly characterized by hyperglycemia. The decline in β-cell function and insulin resistance still remains the major pathophysiological mechanisms of disease progression. By the time T2DM is diagnosed, the β-cell function is already lost halfway, which further declines each year thereafter. The majority of the currently present therapy focuses more on achieving glycemic targets without dealing with the deteriorating β-cell function. Various classes of drugs in managing T2DM aids in improving β-cell function and proliferation including newer agents like Glucagon Like Polypeptide-1 Receptor Agonist (GLP-1RA), Sodium-Glucose Co-Transporter-2 inhibitors (SGLT2i) and Dipeptidyl-Peptidase 4 inhibitors (DPP4i). This review highlights the fate of β-cell function during T2DM progression and the therapeutic approach for β-cell preservation with special emphasis on DPP4i.

Keywords

Type 2 Diabetes (T2DM), β-cell preservation, Dipeptidyl-Peptidase 4 inhibitors (DPP4i), Sitagliptin.
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  • Beta Cell Centric Approach in the Management of Diabetes

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Authors

Dr. Manish Maladkar
President-Medical & Regulatory Affairs, Dept. of Scientific;, India
Dr. Shrikant Patil
Deputy General Manager-Medical, Dept. of Scientific, India
Dr. Ashok Yadav
Assistant General Manager-Medical, Dept. of Scientific;, India
Charul Lautre
Senior Executive-Scientific, Dept. of Scientific, Aristo Pharmaceuticals Private Limited,, India

Abstract


Type 2 Diabetes (T2DM) is a complex, progressive, chronic metabolic disorder that is mainly characterized by hyperglycemia. The decline in β-cell function and insulin resistance still remains the major pathophysiological mechanisms of disease progression. By the time T2DM is diagnosed, the β-cell function is already lost halfway, which further declines each year thereafter. The majority of the currently present therapy focuses more on achieving glycemic targets without dealing with the deteriorating β-cell function. Various classes of drugs in managing T2DM aids in improving β-cell function and proliferation including newer agents like Glucagon Like Polypeptide-1 Receptor Agonist (GLP-1RA), Sodium-Glucose Co-Transporter-2 inhibitors (SGLT2i) and Dipeptidyl-Peptidase 4 inhibitors (DPP4i). This review highlights the fate of β-cell function during T2DM progression and the therapeutic approach for β-cell preservation with special emphasis on DPP4i.

Keywords


Type 2 Diabetes (T2DM), β-cell preservation, Dipeptidyl-Peptidase 4 inhibitors (DPP4i), Sitagliptin.

References