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Acromegaly - Case Series
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Acromegaly is a clinical syndrome with isolated cases globally. Patients may remain undiagnosed for several years after the onset of initial signs and symptoms. Timely diagnosis and initiation of its treatment play a crucial role in patients with Acromegaly. In this article, we present physical, biochemical, and radiological characteristics in a set of 6 cases that may aid in prompt diagnosis and appropriate management of Acromegaly
Keywords
Acromegaly, insulin-like growth factors, hyperprolactinemia, macroadenoma, microadenoma.
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- Daly AF, Petrossians P, Beckers A. An overview of the epidemiology and genetics of acromegaly. J Endocrinol Invest. 2005;28(11 Suppl International):67-9. PMID: 16625848.
- Schneider HJ, Sievers C, Saller B, Wittchen HU, Stalla GK. High prevalence of biochemical acromegaly in primary care patients with elevated IGF-1 levels. Clin Endocrinol (Oxf). 2008 Sep;69(3):432-5. DOI: 10.1111/j.1365-2265.2008.03221.x. Epub 2008 Feb 13. PMID: 18284644.
- Dekkers OM, Biermasz NR, Pereira AM, Romijn JA, Vandenbroucke JP. Mortality in acromegaly: a metaanalysis. J Clin Endocrinol Metab. 2008 Jan;93(1):61-7. DOI: 10.1210/ jc.2007-1191. Epub 2007 Oct 30. PMID: 17971431.
- Melmed S. Medical progress: Acromegaly. N Engl J Med. 2006 Dec 14;355(24):2558-73. DOI: 10.1056/NEJMra062453. Erratum in: N Engl J Med. 2007 Feb 22;356(8):879. PMID: 17167139.
- Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014 Nov;99(11):3933-51. DOI: 10.1210/jc.2014-2700. Epub 2014 Oct 30. PMID: 25356808.
- Park KH, Lee EJ, Seo GH, Ku CR. Risk for Acromegalyrelated Comorbidities by Sex in Korean Acromegaly. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz317. DOI: 10.1210/clinem/dgz317. PMID: 31903478.
- Moon JH, Ryu CH, Cho SW, Choi JY, Chung EJ, Hah JH, Hwangbo Y, et al. Effect of Initial Treatment Choice on 2-year Quality of Life in Patients with Low-risk Papillary Thyroid Microcarcinoma. J Clin Endocrinol Metab. 2021 Mar 8;106(3):724-735. DOI: 10.1210/clinem/dgaa889. PMID: 33248442.
- Lenders NF, McCormack AI, Ho KKY. Management Of Endocrine Disease: Does gender matter in the management of acromegaly? Eur J Endocrinol. 2020 May;182(5):R67-R82. DOI: 10.1530/EJE-19-1023. PMID: 32069216.
- Aljabri KS, Bokhari SA, Assiri FY, Alshareef MA, Khan PM. The epidemiology of pituitary adenomas in a community-based hospital: a retrospective single center study in Saudi Arabia. Ann Saudi Med. 2016 Sep-Oct;36(5):341-345. DOI: 10.5144/0256-4947.2016.341. PMID: 27710986; PMCID: PMC6074317.
- Dimaraki EV, Jaffe CA, DeMott-Friberg R, Chandler WF, Barkan AL. Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up. J Clin Endocrinol Metab. 2002 Aug;87(8):3537-42. DOI: 10.1210/ jcem.87.8.8658. PMID: 12161471.
- Akirov A, Masri-Iraqi H, Dotan I, Shimon I. The Biochemical Diagnosis of Acromegaly. J Clin Med. 2021 Mar 9;10(5):1147. DOI: 10.3390/jcm10051147. PMID: 33803429; PMCID: PMC7967116.
- Ranke MB, Mullis P-E (eds): Diagnostics of Endocrine Function in Children and Adolescents, ed 4. Basel, Karger, 2011:183–93. DOI: 10.1159/isbn.978-3-8055-9415-8
- Van Laethem D, Michotte A, Cools W, Velkeniers B, Unuane D, Andreescu CE, Bravenboer B. Hyperprolactinemia in Acromegaly is Related to Prolactin Secretion by Somatolactotroph Tumours. Horm Metab Res. 2020 Sep;52(9):647-653. DOI: 10.1055/a-1207-1132. Epub 2020. PMID: 32757187.
- Trainer PJ, Drake WM, Perry LA, Taylor NF, Besser GM, Monson JP. Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly. J Clin Endocrinol Metab. 2001 Jul;86(7):2989-92. DOI: 10.1210/jcem.86.7.7664. PMID: 11443156.
- Ortiz R, Kluwe B, Odei JB, Echouffo Tcheugui JB, Sims M, Kalyani RR, Bertoni AG, Golden SH, Joseph JJ. The association of morning serum cortisol with glucose metabolism and diabetes: The Jackson Heart Study. Psychoneuroendocrinology. 2019 May;103:25-32. DOI: 10.1016/j.psyneuen.2018.12.237. Epub 2018 Dec 27. PMID: 30623794; PMCID: PMC6450778.
- Popielarz-Grygalewicz A, Gąsior JS, Konwicka A, Grygalewicz P, Stelmachowska-Banaś M, Zgliczyński W, Dąbrowski M. Heart in Acromegaly: The Echocardiographic Characteristics of Patients Diagnosed with Acromegaly in Various Stages of the Disease. Int J Endocrinol. 2018;11:6935054.
- Lugo G, Pena L, Cordido F. Clinical manifestations and diagnosis of acromegaly. Int J Endocrinol. 2012;2012:540398. DOI: 10.1155/2012/540398. Epub 2012 Feb 1. PMID: 22518126; PMCID: PMC3296170.
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