The Indian Practitioner

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Heart-type Fatty Acid-binding Protein (H-FABP) as an Early Diagnostic and Reperfusion Biomarker in Patients with Acute Chest Pain and its Correlation with Echocardiographic Left Ventricular Ejection Fraction and Angiographic Spectrum of Coronary Vessels


Affiliations
1 Assistant Professor of Cardio, India
2 Senior Professor of (Med) and Principal & Controller, India
3 Professor of Biochemistry, Department of Cardiology, Jawahar Lal Nehru Hospital and Medical College, Ajmer, India
     

   Subscribe/Renew Journal


Background and Aims: Heart-type fatty acid-binding protein (H-FABP) is a novel marker of myocardial injury, released rapidly (<1 h) after the onset of myocardial injury and plays an important role in both early diagnoses of high-risk patients presenting with chest pain as well as an early reperfusion marker in post-thrombolytic patients. We aim to assess and compare the efficacy of H-FABP as an early marker of cardiac injury with Troponin I (cTnI) and creatinine Phospholinase Kinase (CPK-MB) and to correlate it with Left ventricular Ejection Fraction (LVEF)and percentage of stenosis in Coronary arteries. Material and Methods: Total of 300 patients (STEMI 150 and NSTEMI 150) with acute chest pain attending the emergency department within 6 hours after the onset of chest pain were included. Peripheral venous blood samples were obtained on admission, post thrombolysis at 60 minutes, and after 6 and 12 hours to measure a panel of conventional biomarkers FABP, cTnI and CPK. Echocardiography assessed Simpson’s LVEF and Trans mitral Doppler flow and the spectrum of coronary artery disease was defined by Coronary Angiography. Conclusion: FABP could reliably diagnose AMI patients 1 to 3 hours after admission over CPK MB and Troponin I and could also assess post-thrombolysis reperfusion in STEMI patients noninvasively over coronary angiography

Keywords

Heart fatty acid binding protein, Creatinine phosphokinase MB, Troponin I
Subscription Login to verify subscription
User
Notifications
Font Size


  • Nakata T, Hashimoto A, Hase M. Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome. Cardiology. 2003; 99:96– 104.

  • Christopher Carroll et al. Heart-type fatty acid binding protein as an early marker for myocardial infarction: systematic review and meta-analysis. Emerg Med J. 2013; 30:280-6

  • Demet Menekşe Gerede et al. Comparison of a qualitative measurement of heart-type fatty acid-binding protein with other cardiac markers as an early diagnostic marker in the diagnosis of non-ST-segment elevation myocardial infarction. Cardiovasc J Afr. Nov-Dec 2015; 26:204-9.

  • Murat Orak et al. The role of the heart-type fatty acid binding protein in the early diagnosis of the acute coronary syndrome and its comparison with troponinI and creatine kinase-MB isoform. Am J Emerg Med. 2010 Oct.; 28:891-6.

  • Harsh Goel et al Heart-type fatty acid-binding protein: an overlooked cardiac biomarker. Ann Med 2020 Dec;52(8):444- 461. doi: 10.1080/07853890.2020.1800075.

  • M J de Groot et al Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma. Heart 2001 Mar;85(3):278-85. doi: 10.1136/heart.85.3.278.

  • J A de Lemos et al Heart-type fatty acid binding protein as a marker of reperfusion after thrombolytic therapy. Clin Chim Acta 2000 Aug;298(1-2):85-97. doi: 10.1016/s0009- 8981(00)00259-x.

  • J P Bertinchant et al Diagnostic and prognostic value of hearttype fatty acid-binding protein (H-FABP), an early biochemical marker of myocardial injury. Arch Mal Coeur Vaiss 2005 Dec; 98(12):1225-31.


Abstract Views: 280

PDF Views: 0




  • Heart-type Fatty Acid-binding Protein (H-FABP) as an Early Diagnostic and Reperfusion Biomarker in Patients with Acute Chest Pain and its Correlation with Echocardiographic Left Ventricular Ejection Fraction and Angiographic Spectrum of Coronary Vessels

Abstract Views: 280  |  PDF Views: 0

Authors

Dr. Monika Maheshwari
Assistant Professor of Cardio, India
Dr. V.B. Singh
Senior Professor of (Med) and Principal & Controller, India
Dr. Deepa Thadanil
Professor of Biochemistry, Department of Cardiology, Jawahar Lal Nehru Hospital and Medical College, Ajmer, India

Abstract


Background and Aims: Heart-type fatty acid-binding protein (H-FABP) is a novel marker of myocardial injury, released rapidly (<1 h) after the onset of myocardial injury and plays an important role in both early diagnoses of high-risk patients presenting with chest pain as well as an early reperfusion marker in post-thrombolytic patients. We aim to assess and compare the efficacy of H-FABP as an early marker of cardiac injury with Troponin I (cTnI) and creatinine Phospholinase Kinase (CPK-MB) and to correlate it with Left ventricular Ejection Fraction (LVEF)and percentage of stenosis in Coronary arteries. Material and Methods: Total of 300 patients (STEMI 150 and NSTEMI 150) with acute chest pain attending the emergency department within 6 hours after the onset of chest pain were included. Peripheral venous blood samples were obtained on admission, post thrombolysis at 60 minutes, and after 6 and 12 hours to measure a panel of conventional biomarkers FABP, cTnI and CPK. Echocardiography assessed Simpson’s LVEF and Trans mitral Doppler flow and the spectrum of coronary artery disease was defined by Coronary Angiography. Conclusion: FABP could reliably diagnose AMI patients 1 to 3 hours after admission over CPK MB and Troponin I and could also assess post-thrombolysis reperfusion in STEMI patients noninvasively over coronary angiography

Keywords


Heart fatty acid binding protein, Creatinine phosphokinase MB, Troponin I

References