TROXIPIDE: A Novel Cytoprotective Agent in Acid Peptic Disorders

Gastritis and gastric ulcers are highly prevalent diseases among the Asian population. Patients approach for treatment only when disease related symptoms become severe.1 Treatment of gastric ulcers varies depending on the aetiology and clinical presentation. Acid suppression is the general pharmacologic principle of medical management of acute bleeding from a peptic ulcer, using histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) and cytoprotective agents (antacids, sucralfate).2 All these agents are available in intravenous or oral preparations and their efficacy is well established. Gastric defensive factors play a much significant role in gastric disorders so there was a need for drugs to normalise the gastric mucosal constitution and other defensive mediators including cytoprotective prostaglandins and gastric microcirculation.