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Jaundice in Pregnancy


Affiliations
1 Department of Obstetrics and Gynaecology, Kamla Nehru State Hospital for Mother & Child, Shimla, India
2 Department of Gastroenterology, Kamla Nehru State Hospital for Mother & Child, Shimla, India
     

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In a 2 year period, 18 pregnant women with jaundice were admitted from March 2008 to March 2010 to study the maternal and foetal outcome. 50% of women were unbooked, 33% were referred cases, and 72% were in their third trimester of pregnancy. Serum bilirubin was > 5 mg% in 38.8% of women. Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase were raised in a majority of women. Out of 18 women 15(83.3%) delivered, 2 (11.1%) remained undelivered and 1 (5.5%) women aborted, 72% of women delivered vaginally. Maternal mortality was 22.2%. Cause of death was hepatic encephalopathy with renal failure in 16.6% of the women and hepatic encephalopathy with renal failure with severe anaemia with disseminated intravascular coagulopathy (DIC) in 5.5% of women. Perinatal mortality was 27%, all stillbirths. Jaundice in pregnancy is an important medical disorder requiring early diagnosis and management.

Keywords

Jaundice, Viral Hepatitis, Intrahepatic Cholestasis of Pregnancy, Acute Fatty Liver of Pregnancy (AFLP).
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  • Jaundice in Pregnancy

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Authors

S. Thakur
Department of Obstetrics and Gynaecology, Kamla Nehru State Hospital for Mother & Child, Shimla, India
A. Pal
Department of Obstetrics and Gynaecology, Kamla Nehru State Hospital for Mother & Child, Shimla, India
R. C. Negi
Department of Gastroenterology, Kamla Nehru State Hospital for Mother & Child, Shimla, India

Abstract


In a 2 year period, 18 pregnant women with jaundice were admitted from March 2008 to March 2010 to study the maternal and foetal outcome. 50% of women were unbooked, 33% were referred cases, and 72% were in their third trimester of pregnancy. Serum bilirubin was > 5 mg% in 38.8% of women. Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase were raised in a majority of women. Out of 18 women 15(83.3%) delivered, 2 (11.1%) remained undelivered and 1 (5.5%) women aborted, 72% of women delivered vaginally. Maternal mortality was 22.2%. Cause of death was hepatic encephalopathy with renal failure in 16.6% of the women and hepatic encephalopathy with renal failure with severe anaemia with disseminated intravascular coagulopathy (DIC) in 5.5% of women. Perinatal mortality was 27%, all stillbirths. Jaundice in pregnancy is an important medical disorder requiring early diagnosis and management.

Keywords


Jaundice, Viral Hepatitis, Intrahepatic Cholestasis of Pregnancy, Acute Fatty Liver of Pregnancy (AFLP).