Comparison of the Maternal and Foetal Outcome in Induction of Labour by Sublingual and Vaginal Misoprostol

Purpose of the Study: To compare the efficacy and safety of sublingual versus vaginal misoprostol for induction of labour in term pregnancy.

Materials and Methods: A total of 100 women admitted for induction of labour at PGIMS Rohtak were randomized to receive 25 μg of sublingual versus vaginal misoprostol for induction of labour.

Results: Majority of women in both groups delivered vaginally (90% in both the groups). The mean number of doses of misoprostol required for induction of labour was similar in sublingual and vaginal misoprostol groups (1.64±0.802 versus 1.96±1.12). The time taken from induction to active phase of labour was 5.72±3.59 versus 7.04±4.55 (hours) in the both the groups respectively. The induction delivery interval was 8.38 (hours) in the sublingual and 7.04 (hours) in the vaginal misoprostol groups. Most of the patients in both the groups did not require oxytocin for augmentation of labour.

Conclusion: The low dose of misoprostol i.e. 25 μg is equally efficacious and safe by both sublingual and vaginal routes.