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In Vitro Study on the Protective Effect of Centella asiatica< (Thankuni) in Fish Roe Induced Hyperuricaemic Rats
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Hyperuricaemia is a disorder of purine metabolism which is frequently encountered in the clinical setting. The current in vitro study aims at finding out the effect of dietary purine intake on serum uric acid levels and the efficacy of Centella asiatica for treating this condition. Male Wistar rats of Group C, P and PT received stock diet, stock diet+fish roe (5g/day), stock diet+fish roe (5g/day)+Centella asiatica (150mg/kg) paste respectively. In PT group, serum uric acid decreased as compared to P, and it was comparable to C group. The herb also showed positive effect on liver function tests. It can be concluded that Centella asiatica can act as a potent herbal remedy in hyperuricaemia as well as gout.
Keywords
Hyperuricaemia, Gout, Liver Function, Herbal Remedy.
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- S Davidson, Davidson’s Principles and Practice of Medicine,Churchill Livingstone Publishers, Edinburgh, Vol 12, page 831-835, 1999.
- S Raja, A Kumar, R D Aahooja, U Thakuria, S Ochani, F Shaukat, Frequency of Hyperuricemia and its Risk Factors in the Adult Population, Cureus Journal of Medical Science,Cureus, San Francisco, Vol 11, No 3, page e4198, 2019.
- S Sen. Studies on Physiological and Nutritional Importance of Centella asiatica with Special Reference to Uric Acid Level of Blood. Thesis. University of Calcutta, Kolkata. Shodhganga, 2009. Available from: http://hdl.handle.net/10603/162403.
- S Sen, S Dutta, A Comprehensive Review on Thankuni (Centella asiatica) as an Herbal Remedy in Diabetes Mellitus and Wound Healing, Journal of Pharmacognosy and Phytochemistry, AkiNik Publications, Delhi 110085, Vol 9, No 5, page 120129, 2020.
- N Raghuramulu, K M Nair, S KalyanSundaram. A Manual of Laboratory Techniques, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500 007, Vol 1, page 57-61, 1983.
- J Sharma, R Sharma, Radioprotection of Swiss albino mouse by Centella asiatica extract,Phytother Res, John Wiley & Sons Ltd, Hoboken, Vol 16, No 8, page 785-786, 2002.
- D Barham, P Trinder, An Improved Colour Reagent for the Determination of Blood Glucose by the Oxidase System, Analyst, Royal Society of Chemistry, London, Vol 97, page 142-145, 1972.
- P R Kind, E J King, Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine, J ClinPathol, BMJ Group, London, Vol 7, No 4, page 322-326, 1954.
- [9] S Reitman, S Franken,A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases, Am J ClinPathol, Oxford University Press, Oxford, Vol 28, No 1, page 56-63, 1957.
- D A Arvan, M Coyle, Serum and tissue alanine aminotransferase (GPT) based on optimal substrate concentration, Clin Chem, Oxford University Press, Oxford, Vol 15, page 785, 1969.
- H J Conn, M A Darrow, Staining procedure Part I, Animal histology, Williams and Williams, Baltimore, Vol 2, 1947.
- R D Hotchkiss, A micro chemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations, Archives of Biochemistry, New York Academic Press, United States,Vol 16, page 131, 1948.
- SPSS. (1996) SPSS Base 7.0 Windows User’s Guide. SPSS Inc., Chicago, IL.
- J Aucamp, A Gaspar, N Schlesinger, Dietary Factors and Hyperuricemia,Curr Pharm Des, Bentham Science Publishers, Sharjah, Vol 11, No 32, page 4133-4138, 2005.
- J Aucamp, A Gaspar, Y Hara, Z Apostolides, Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis), Anticancer Res,International Institute of Anticancer Research, Greece, Vol 17, No 6D, page 4381-4385, 1997.
- J George, A D Struthers, Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress, Vascular Health and RiskManagement, Dove Medical Press, Manchester, Vol 5, No 1, page 265-272, 2009.
- Y K Gupta, M H V Kumar, A K Srivastava, Effect of C.asiatica on pentylenetetrazole- induced kindling, cognition and oxidative stress in rats, Pharmacology Biochemistry and Behaviour,Elsevier, Vol 74, No 3, page 579-585, 2003.
- G K Shinomol, Muralidhara, Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions ofprepubertal mice,Neurotoxicology, Elsevier, Vol 29, No 6, page 948-957, 2008.
- M Hussin, A AHamid, S Mohamad, N Saari, F Bakar, S P Dek, Modulation of lipid metabolism by Centella asiatica in oxidative stress rats, J Food Sci,John Wiley & Sons, Institute of Food Technologists, Chicago, Vol 74, No 2, page H72-78, 2009.
- K Cimanga, L Ying,T De Bruyne et al, Radical scavenging and xanthine oxidase inhibitory activity of phenolic compounds from Brideliaferruginea stem bark, Journal of Pharmacy andPharmacology, Wiley-Blackwell, Royal Pharmaceutical Society of Great Britain, London, Vol 53, No 5, page 757-761, 2001.
- H Y Huang, U Appel, M J Choi, A C Gelber, J Charleston, E P Norkus, E R Miller ER, The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized, controlled trial, Arthritis Rheum, American College of Rheumatology, Atlanta, Vol 52, page 1843-1847, 2005.
- H K Choi, X Gao, G Curban, Vitamin C intake and the risk of gout in men: a prospective study, Arch Intern Med, American Medical Association, Chicago, Vol 169, No 5, page 502-507, 2009.
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