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History of Development of Some Popular Organic Pharmaceuticals
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The use of medicine originated way back from the time of ancient Civilization. Modern drug design is a complex process based on profound understanding of cellular biochemistry, pathology and synthetic chemistry. The current article presents an overview on medicine from antiquity to new age pharmacology. Here, background of development of antibiotics, antibacterial and antiviral agents and HIV-AIDS related drugs is discussed, with special mention of their synthetic procedures as well as mechanism of actions. This article is a tribute to the great scientific minds behind the discovery of highly successful drugs like Sulfonamides, Acyclovir, Retrovir which have been saving millions of lives.
Keywords
Ancient medicines, New age pharmacology, Antibiotics, Sulfonamides, Acyclovir, Retrovir.
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- G Patrick, Introduction to Medicinal Chemistry, Oxford University Press, 2005.
- T L Lemke, D A Williams, Foye’s Principles of Medicinal Chemistry, Fifth Edition,Lippincott & Wilkins, 2002.
- J M Beale, J H Block, Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry,Eleventh Edition, Lippincott & Wilkins, 2004.
- T J Dougherty, M J Pucci, Antibiotic Discovery and Development, Springer Science & Business Media, 2011.
- C G Smith, J T O’Donnell, The Process of New Drug Discovery and Development, Second Edition, Informa Healthcare, 2006.
- F Bosch, L Rosich, The contributions of Paul Ehrlich to pharmacology: a tribute onthe occasion of the centenary of his Nobel Prize, Pharmacology, Karger, Vol82, No 3, page 171–179, 2008.
- M Lobanovska, P Giulia, Penicillin’s discovery and antibiotic resistance: lessons for the future?, Yale Journal of Biology and Medicine, PubMed Central (United States), Vol 90, No 1, page 135–145, 2017.
- J Davies, D Davies, Origins and evolution of antibiotic resistance, Microbiology and Molecular Biology Review, American Society for Microbiology,Vol74, No 3, page417–433, 2010.
- H Otten, Domagk and the development of the sulphonamides, The Journal of Antimicrobial Chemotherapy, Oxford Academic, Vol17, No 6, page 689–696, 1986.
- E F A Fourneau, J G M Tréfouel, F Nitti, D Bovet, T B Tréfouel, Actionantistreptococcique des derives sulfurés organiques, Comptes Rendus de l’Academie des Sciences, French Academy of Sciences, Vol 204, page 1763-1766, 1937.
- D D Woods, The relation of p-aminobenzoic acid to the mechanism of the action of sulphanilamide, British Journal of Experimental Pathology, PMC, Vol 21, page 74-90, 1940.
- H J Schaeffer, L Beauchamp, P de Miranda, G B Elion, D J Bauer, P Collins, 9-(2-Hydroxyethoxymethyl) guanine activity against viruses of the herpes group, Nature, Nature Research, Vol 272, page 583–585, 1978.
- G B Elion, P A Furman, J A Fyfe, P De Mirouds, L Beauchamp, H J Schaeffer, Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine, Proceedings of the National Academy of Sciences, United States National Academy of Sciences,Vol74, page 5716-5720, 1977.
- G H Hitchings, G B Elion, Chemical suppression of the immune response, Pharmacological Reviews, American Society for Pharmacology and Experimental Therapeutics (United States), Vol15, No 2, page 365-405, 1963.
- EP Acosta, L M Page, CV Fletcher, Clinical Pharmacokinetics of Zidovudine, Clinical Pharmacokinetics, Springer, Vol 30, page 251–262, 1996.
- E De Clercq, HIV resistance to reverse-transcriptase inhibitors, Biochemical Pharmacology, Elsevier, Vol 47, No 2, page 155–169, 1994.
- S Broder, The development of antiretroviral therapy and its impact on the HIV1/AIDS pandemic, Antiviral Research, Elsevier,Vol85, No 1, page 1–2, 2009.
- P Furman, J Fyfe, M St Clair, K Weinhold, J Rideout, G Freeman, S Lehrman, D Bolognesi, S Broder, H Mitsuya, Phosphorylation of 3’-azido3’-deoxythymidine and selective interaction of the 5’-triphosphate with human immunodeficiency virus reverse transcriptase, Proceedings of the National Academy of Sciences, United States National Academy of Sciences,Vol83, No 21, page 8333–8337, 1986.
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