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Super-Chromosomes: Novelties of Leukocyte Nucleus Redefine Chromosomes


Affiliations
1 Tumorcytogenetics Lab, Children’s Policlinic, LMU, Munich, Email: jyotichaudhuri@gmail.com, India
     

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Contrary to the prevailing concept, human and mammalian chromosomes have a defined order. Both at metaphase and interphase the two homologous chromosomes tend to lie opposite each other causing a separation of the two genomes, i.e. the two parental sets of chromosomes. Each of the two chromosome sets forms a continuous chain. They join in a ring or chain to form a super-chromosome and maintain one continuous linear order of the genes during interphase and facilitate gene expression and control of alleles. The laterality of the nucleus, generated by the separation of the two sets of chromosomes, supports cellular polarity needed for immune, neuronal and secretory functions .

Keywords

chromosomes, molecular genetics, ring-shaped nuclei, Hi-C, genomes, and epigenetics
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  • Super-Chromosomes: Novelties of Leukocyte Nucleus Redefine Chromosomes

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Authors

Jyoti P Chaudhuri
Tumorcytogenetics Lab, Children’s Policlinic, LMU, Munich, Email: jyotichaudhuri@gmail.com, India

Abstract


Contrary to the prevailing concept, human and mammalian chromosomes have a defined order. Both at metaphase and interphase the two homologous chromosomes tend to lie opposite each other causing a separation of the two genomes, i.e. the two parental sets of chromosomes. Each of the two chromosome sets forms a continuous chain. They join in a ring or chain to form a super-chromosome and maintain one continuous linear order of the genes during interphase and facilitate gene expression and control of alleles. The laterality of the nucleus, generated by the separation of the two sets of chromosomes, supports cellular polarity needed for immune, neuronal and secretory functions .

Keywords


chromosomes, molecular genetics, ring-shaped nuclei, Hi-C, genomes, and epigenetics

References





DOI: https://doi.org/10.24906/isc%2F2022%2Fv36%2Fi5%2F218000