International Journal of Medical Sciences

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Acacia senegal Possesses in vitro Cytotoxicity Against Human Cancer Cells


Affiliations
1 Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology (J.), Chatha, Jammu (J&K), India
     

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In vitro assay for cytotoxic activity of Acacia senegal has been carried out against four human cancer cell lines from four different tissues via aqueous extract at the concentration of 10, 30 and 100 μg/ml using Sulphorhodamine blue (SRB) assay. Results revealed that fruit and seed part of the plant showed remarkable in vitro cytotoxic potential against three human cancer cells of cervical (SiHa), neuroblastoma (IMR-32) and lung (A-549) origin at the concentration of 30 and 100 μg/ml. Based on in vitro data, it is suggested that further in vivo studies as well as identification of effective components could be useful in designing new anti-cancer therapeutic agents from this particular plant.

Keywords

Acacia senegal, Human Cancer Cells, Neuroblastoma.
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  • Acacia senegal Possesses in vitro Cytotoxicity Against Human Cancer Cells

Abstract Views: 357  |  PDF Views: 1

Authors

Vikas Sharma
Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology (J.), Chatha, Jammu (J&K), India

Abstract


In vitro assay for cytotoxic activity of Acacia senegal has been carried out against four human cancer cell lines from four different tissues via aqueous extract at the concentration of 10, 30 and 100 μg/ml using Sulphorhodamine blue (SRB) assay. Results revealed that fruit and seed part of the plant showed remarkable in vitro cytotoxic potential against three human cancer cells of cervical (SiHa), neuroblastoma (IMR-32) and lung (A-549) origin at the concentration of 30 and 100 μg/ml. Based on in vitro data, it is suggested that further in vivo studies as well as identification of effective components could be useful in designing new anti-cancer therapeutic agents from this particular plant.

Keywords


Acacia senegal, Human Cancer Cells, Neuroblastoma.

References