Anti-Diabetic Potential of Vitis Vinifera Root Extract Against Streptozotocin Induced Diabetic Rats

India has become the diabetic capital of the world with highest number of patients suffering from this metabolic disorder affecting children, youth and senior citizens of our country. Therefore, this project was undertaken to investigate the potential of grape ischolar_main in the management of Streptozotocin-induced hyperglycemia in rats. The anti-diabetic activity of 95% ethanolic extract of ischolar_mains of Vitis vinifera (commonly known as Angoor) was investigated. The dose 500 mg/kg of body weight appeared to be the effective dose as it caused the maximum lowering of the fasting blood glucose, in Streptozotocin-Nicotinamide induced Type II diabetic rats. The maximum hypoglycemic effect was observed at the 4th h to which the study has been conducted. Administration of the effective dose of the extract to diabetic rats for 15 days showed favorable effects not only on fasting blood glucose, but also on cholesterol and liver glycogen levels. Vitis vinifera reflected a high margin of safety, as no mortality was observed even after the administration of the extract at the dose of 5g/kg body weight. Thus Vitis vinifera ischolar_main appears to be a promising candidate for developing a new Anti-diabetic remedy.