International Journal of Medical Sciences

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Ischemia-Reperfuson Injury and Oxidative Damage in Human Liver Transplantation


Affiliations
1 Department of Biochemistry, Dr. D.Y. Patil Medical College, Kolhapur (M.S.), India
2 Department of Biochemistry, Rajarshee Chhatraputi Shahu Maharaj (RCSM) Govt. Medical College, Shenda Park, Kolhapur (M.S.), India
3 Department of Biochemistry, Global Hospitals, Hyderabad (A.P.), India
     

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The aim of this study was to evaluate oxygen-dependent hepatic injury in human being following liver transplantation. Total 30 patients underwent liver transplantation. Blood samples were taken at different stages of transplantation for determination of the levels of serum lipid peroxide and serum nitric oxide. It was observed that the level of serum lipid peroxide and serum nitric oxide increased maximum at the stage of reperfusion than that of pre-reperfusion and post-reperfusion stages. These findings indicate that significant generation of ROS during I/R injury plays crucial role in the pathogenesis of liver damage in human liver transplantation.

Keywords

Lipid Peroxide, Nitric Oxide, ROS, I/R Injury.
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  • Ischemia-Reperfuson Injury and Oxidative Damage in Human Liver Transplantation

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Authors

Vaishali N. Thorat
Department of Biochemistry, Dr. D.Y. Patil Medical College, Kolhapur (M.S.), India
Adinath N. Suryakar
Department of Biochemistry, Rajarshee Chhatraputi Shahu Maharaj (RCSM) Govt. Medical College, Shenda Park, Kolhapur (M.S.), India
Pradeep Naik
Department of Biochemistry, Global Hospitals, Hyderabad (A.P.), India
Bipin M. Tiwale
Department of Biochemistry, Dr. D.Y. Patil Medical College, Kolhapur (M.S.), India

Abstract


The aim of this study was to evaluate oxygen-dependent hepatic injury in human being following liver transplantation. Total 30 patients underwent liver transplantation. Blood samples were taken at different stages of transplantation for determination of the levels of serum lipid peroxide and serum nitric oxide. It was observed that the level of serum lipid peroxide and serum nitric oxide increased maximum at the stage of reperfusion than that of pre-reperfusion and post-reperfusion stages. These findings indicate that significant generation of ROS during I/R injury plays crucial role in the pathogenesis of liver damage in human liver transplantation.

Keywords


Lipid Peroxide, Nitric Oxide, ROS, I/R Injury.