International Journal of Medical Sciences

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Development of New UV Spectrophotometric Method for Estimation of Losartan Potasium in Bulk and Tablet Dosage Form


Affiliations
1 Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyala, Haridwar (Uttarakhand), India
2 Department of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Sciences, Dehradun (Uttarakhand), India
3 Department of Pharmacy, Bharat Institute of Technology, Meerut (U.P.), India
4 Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalay, Sagar (M.P.), India
     

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A new, simple, specific, precise and accurate spectrophotometric method has been developed for determination of losartan potassium in bulk and tablet dosage form. The drug shows absorption maxima at 228 nm. The method was statistically validated according to I.C.H. Guidelines. Percentage mean recovery obtained was 99.62%; coefficient of variance was found to be less than 2% and linearity coefficient was 0.9995. Linear response obtained for losartan potassium was in the concentration range of 2-18 μg/ml. The limit of detection and limit of quantification for Losartan was found to be 0.086 μg/ml and 0.259 μg/ml, respectively.

Keywords

Losartan Potassium, Spectrophotometric, Validation.
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  • Development of New UV Spectrophotometric Method for Estimation of Losartan Potasium in Bulk and Tablet Dosage Form

Abstract Views: 236  |  PDF Views: 0

Authors

Kapil Kumar Goel
Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyala, Haridwar (Uttarakhand), India
Nidhi Goel
Department of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Sciences, Dehradun (Uttarakhand), India
Shailendra Patil
Department of Pharmacy, Bharat Institute of Technology, Meerut (U.P.), India
Asmita Gajbhiye
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalay, Sagar (M.P.), India

Abstract


A new, simple, specific, precise and accurate spectrophotometric method has been developed for determination of losartan potassium in bulk and tablet dosage form. The drug shows absorption maxima at 228 nm. The method was statistically validated according to I.C.H. Guidelines. Percentage mean recovery obtained was 99.62%; coefficient of variance was found to be less than 2% and linearity coefficient was 0.9995. Linear response obtained for losartan potassium was in the concentration range of 2-18 μg/ml. The limit of detection and limit of quantification for Losartan was found to be 0.086 μg/ml and 0.259 μg/ml, respectively.

Keywords


Losartan Potassium, Spectrophotometric, Validation.