Renal Function Tests in Pediatric Patients with Minimal Change Steroid-Responsive Nephrotic Syndrome

Objectives: To determine renal function tests in children with minimal change disease (MCD).
Study Design: Prospective Setting: MCD patients from pediatric ward, P.V.P. General Hospital, Sangli as well as General Hospital, Miraj.
Participants: The study group comprised of 30 children with minimal change disease (mean age=4.73±2.04 years) and control group of 30 children matching in age and sex.
Methods: Venous blood samples were collected in test tube with aseptic precautions. The sera with no sign of hemolysis used for the analysis of urea, creatinine, uric acid and electrolytes. After collection of blood sample early morning urine sample were collected on the next day. The fresh urine sample was collected and part of which diluted for urea and creatinine estimation. Remaining urine was used for estimation of urea, creatinine, total protein and Microalbumin.
Results: A significant alteration of Serum urea, creatinine, uric acid, potassium levels in children with minimal change disease and excretion of urea, creatinine were significantly decreased whereas, total protein, and microalbumin excretion were increased.
Conclusion: These findings suggest that increased levels of these parameters may be an indicator of renal tubular damage and dysfunction.