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Green Tea:A Natural Source of Drug for Liver Cancer
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Green tea (Camellia sinensis) has anticancer activity in animal. The HBx protein of Hepatitis B virus activate AP-1 protein and it causes the down regulation of PTEN and p53 which are tumor suppressor genes, leads to the tumor formation in liver. The interactions between HBx and AP-1 have been targeted by docking of natural compounds. EGCG obtained from green tea shows highest affinity for AP-1 protein among all natural compounds. Affinity of EGCG with AP-1 protein may be used to design drug for liver cancer.
Keywords
Liver Cancer, HBV, Activator Protein-1, Natural Compounds, EGCG, Docking.
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