International Journal of Medical Sciences

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Effect of Novel Heterocyclic Compound on Protein and Lipid Metabolisms in Different Tissues of Male Albino Rats


Affiliations
1 Reproductive Physiology Unit, Department of Zoology, Kakatiya University, Warangal (A.P.), India
2 University College of Pharmaceutical Sciences, Kakatiya University, Warangal (A.P.), India
     

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The present study was carried out on the effect of novel heterocyclic compound on total proteins, free amino acids and total lipids contents in different tissues to understand the protein and lipid metabolisms and their role in male rats. The treatment with Ethyl 1-(2-oxoindolin-3-ylideneamino)-1,2,3,6-tetrahydro-4-methyl-2-oxo-6-phenyl pyrimidine-5-carboxylate compound at dose level of 50mg/kg body weight for 21 days did cause mild changes in proteins and lipid metabolism in reproductive and somatic tissues of treated rats. In order to assess the physiological changes in testis, brain, heart, kidney and liver of rats, estimation of total proteins, free amino acids and total lipids has been under taken. The result showed a mild decrease in total protein levels, but in contrast to the same treatment caused a mild increase in free amino acid and total lipid levels.

Keywords

Novel Heterocyclic Compound, Proteins and Lipid Metabolisms, Physiological Changes, Reproductive Tissue, Somatic Tissues.
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  • Effect of Novel Heterocyclic Compound on Protein and Lipid Metabolisms in Different Tissues of Male Albino Rats

Abstract Views: 210  |  PDF Views: 0

Authors

M. Anil Kumar
Reproductive Physiology Unit, Department of Zoology, Kakatiya University, Warangal (A.P.), India
M. Krishna Reddy
Reproductive Physiology Unit, Department of Zoology, Kakatiya University, Warangal (A.P.), India
M. Sarangapani
University College of Pharmaceutical Sciences, Kakatiya University, Warangal (A.P.), India

Abstract


The present study was carried out on the effect of novel heterocyclic compound on total proteins, free amino acids and total lipids contents in different tissues to understand the protein and lipid metabolisms and their role in male rats. The treatment with Ethyl 1-(2-oxoindolin-3-ylideneamino)-1,2,3,6-tetrahydro-4-methyl-2-oxo-6-phenyl pyrimidine-5-carboxylate compound at dose level of 50mg/kg body weight for 21 days did cause mild changes in proteins and lipid metabolism in reproductive and somatic tissues of treated rats. In order to assess the physiological changes in testis, brain, heart, kidney and liver of rats, estimation of total proteins, free amino acids and total lipids has been under taken. The result showed a mild decrease in total protein levels, but in contrast to the same treatment caused a mild increase in free amino acid and total lipid levels.

Keywords


Novel Heterocyclic Compound, Proteins and Lipid Metabolisms, Physiological Changes, Reproductive Tissue, Somatic Tissues.