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Clinical Evaluation of Aspirin, Clopidogrel and Clopidogrel-Aspirin Combination in Cardiovascular Disease


Affiliations
1 Department of Botany, Kunthavai Nacchiyar Government Arts College for Women, Thanjavur (T.N.), India
2 Department of Environmental and Herbal Sciences, Tamil University, Thanjavur (T.N.), India
3 Department of Biochemistry, Bharathidasan University, Trichy (T.N.), India
     

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Coactivation of platelets and the blood coagulation cascade contributes to the pathophysiology of antithrombotic effect. Combination of antiplatelet drugs may be needed for maximizing the prevention and treatment of thrombosis. Aspirin inhibits platelets by inhibiting cyclooxygenase and was shown to reduce platelet-dependent thrombin generation, whereas clopidogrel inhibits platelet activity by blocking the platelet ADP receptors. The present study demonstrates that clopidogrel was an effective antithrombotic agent. Further the combination of aspirin and clopidogrel increases antithrombotic effect without increasing bleeding time.

Keywords

Coronary Artery Disease or Atherosclerosis and Transient Ischemic Attack.
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  • Clinical Evaluation of Aspirin, Clopidogrel and Clopidogrel-Aspirin Combination in Cardiovascular Disease

Abstract Views: 269  |  PDF Views: 0

Authors

G. Shanthi
Department of Botany, Kunthavai Nacchiyar Government Arts College for Women, Thanjavur (T.N.), India
V. Sivakumari
Department of Environmental and Herbal Sciences, Tamil University, Thanjavur (T.N.), India
S. Giridaran
Department of Biochemistry, Bharathidasan University, Trichy (T.N.), India
R. Prabhu
Department of Biochemistry, Bharathidasan University, Trichy (T.N.), India

Abstract


Coactivation of platelets and the blood coagulation cascade contributes to the pathophysiology of antithrombotic effect. Combination of antiplatelet drugs may be needed for maximizing the prevention and treatment of thrombosis. Aspirin inhibits platelets by inhibiting cyclooxygenase and was shown to reduce platelet-dependent thrombin generation, whereas clopidogrel inhibits platelet activity by blocking the platelet ADP receptors. The present study demonstrates that clopidogrel was an effective antithrombotic agent. Further the combination of aspirin and clopidogrel increases antithrombotic effect without increasing bleeding time.

Keywords


Coronary Artery Disease or Atherosclerosis and Transient Ischemic Attack.