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Evaluation of Thyroid Profile Among The Diabetic Patients in South Indian Rural Population


Affiliations
1 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur (T.N.), India
2 Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar (A.P.), India
3 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), India
     

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Both diabetes and thyroid disorders involve dysfunction of the endocrine system. Almost one third of people with type 1 diabetes have been found to have thyroid disease. Since both diseases are parallel and influence one another. Any alteration in thyroid hormones may have further complication such as CAD. Low T3 syndrome is well established in development of CAD. In the present study we assessed the circulating thyroid hormones and glycemic status among Diabetic population. T3 levels are low in both Type I and II diabetes, and are directly correlated with poor glycemic control. Among the diabetic population women are worse affected than men. In conclusion, many diabetics showed a low T3 levels, suggesting that there may be impairment in the extrathyroidal conversion of T4 to T3 (5' deiodinization) and in turn enhanced by a poor glycemic control. The study reveals that frequent checkup for thyroid hormones are compulsory to prevent further complications.

Keywords

Glycemic Status, Diabetes Mellitus, Thyroid Dysfunction, 5' Deiodinization, Low T3 Syndrome, CAD.
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  • Evaluation of Thyroid Profile Among The Diabetic Patients in South Indian Rural Population

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Authors

K. Satya Narayana
Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur (T.N.), India
Sravanthi Koora
Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar (A.P.), India
Ivvala Anand Shaker
Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), India
S. Saleem Basha
Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), India
K. Suresh Babu
Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), India

Abstract


Both diabetes and thyroid disorders involve dysfunction of the endocrine system. Almost one third of people with type 1 diabetes have been found to have thyroid disease. Since both diseases are parallel and influence one another. Any alteration in thyroid hormones may have further complication such as CAD. Low T3 syndrome is well established in development of CAD. In the present study we assessed the circulating thyroid hormones and glycemic status among Diabetic population. T3 levels are low in both Type I and II diabetes, and are directly correlated with poor glycemic control. Among the diabetic population women are worse affected than men. In conclusion, many diabetics showed a low T3 levels, suggesting that there may be impairment in the extrathyroidal conversion of T4 to T3 (5' deiodinization) and in turn enhanced by a poor glycemic control. The study reveals that frequent checkup for thyroid hormones are compulsory to prevent further complications.

Keywords


Glycemic Status, Diabetes Mellitus, Thyroid Dysfunction, 5' Deiodinization, Low T3 Syndrome, CAD.