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Impact of Vitamin D Status during Gestation Period on Low Birth Weight


Affiliations
1 Department of Food and Nutrition, College of Home Science, Punjab Agricultural University, Ludhiana (Punjab), India
2 Department of Food and Nutrition, College of Home Science, Punjab Agricultural University, Ludhiana (Punjab), India
     

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Low birth weight has been defined by the World Health Organization (WHO) as weight at birth of less than 2,500 g. From conception to birth, the weight of human fetus increases six millions. This rapid growth requires a continuous supply of energy and nutrients which the fetus is unable to synthesize. Maternal socio-economic status, mother's nutrition and diet, lifestyle and other exposures including disease or complications such as hypertension can affect fetal growth and development. Maternal malnutrition causes birth weight reduction. A positive correlation has been seen between maternal and child vitamin D levels. Maternal vitamin D deficiency in early pregnancy has been associated with elevated risk of preterm birth or low birth weight. Low maternal vitamin D status may also slow neonatal cardiac development and alter brain morphology of infant. More recent studies may support the use of vitamin D supplementation during pregnancy to prevent LBW. Maternal total serum calcium levels decline as the pregnancy progresses but during the third trimester, the fetus maintains higher serum calcium levels as a result of active transport of the mineral across the placenta which leads to the low level of calcium in mother. Women at risk of vitamin D deficiency should be monitored and treated during pregnancy for vitamin D deficiency. LBW continues to be a problem of concern as disorders related to LBW and preterm birth are the leading causes of infant mortality. Studies are needed to investigate vitamin D requirements during pregnancy to derive guidelines for health professionals.

Keywords

Vitamin D, Low Birth Weight, Calcium.
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  • Achinger, S.G. and Ayus, J.C. (2005). The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Internat. Suppl., 95: 37-42.

  • Blackburn, S.T. (2013). Maternal, Fetal, & Neonatal Physiology (4 Ed.) Maternal, Fetal, & Neonatal Physiology. Elsevier Health Sciences. 595p.

  • Brooke, O.G., Brown, I.R., Bone, C.D., Carter, N.D., Cleeve, H.J., Maxwell, J.D., Robinson, V.P. and Winder, S.M. (1980). Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br. Med. J., 280: 751–754.

  • Chiu, K.C., Chu, A., Go, V.L. and Saad, M.F. (2004). Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am. J. Clin. Nutr., 79 : 820-825.

  • Cross, N.A., Hillman, L.S., Allen, S.H., Krause, G.F. and Vieira, N.E. (1995). Calcium homeostasis and bone metabolism during pregnancy, lactation and postweaning: a longitudinal study. Am. J. Clin. Nutr., 61: 514-523.

  • Datta, S., Alfaham, M., Davies, D.P., Dunstan, F., Woodhead, S., Evans, J. and Richards, B. (2002). Vitamin D deficiency in pregnant women from a non-European ethnic minority population- an interventional study. BJOG, 109 : 905-908.

  • Deluca, H.F. and Cantorna, M.T. (2001). Vitamin D: its role and uses in immunology. Faseb. J., 15: 2579-2585.

  • Deluca, H.F. and Zierold, C. (1998). Mechanisms and functions of vitamin D. Nutr. Rev., 56 : 4-10.

  • Eisman, J.A., Koga, M., Sutherland, R.L., Barkla, D.H. and Tutton, P.J. (1989). Dihydroxyvitamin D3 and the regulation of human cancer cell replication. Proc. Soc. Exp. Biol. Med., 191: 221-226.

  • Heckmatt, J.Z., Peacock, M., Davies, A.E.J., McMurray, J. and Isherwood, D.M. (1979). Plasma 25-hydroxy vitamin D in pregnant Asian women and their babies. Lancet, 2 : 546-549.

  • Holick, M.F., MacLaughlin, J.A., Clark, M.B., Holick, S.A., Potts, J.T., Jr., Anderson, R.R., Blank, I.H., Parrish, J.A. and Elias, P. (1980). Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Sci.,210 : 203-235.

  • Hollis, B.W., Johnson, D., Hulsey, T.C., Ebeling and M., Wagner, C.L. (2011). Vitamin D supplementation during pregnancy: double blind, randomized clinical trial of safety and effectiveness. J. Bone Miner. Res., 26:2341-2357.

  • Kimball, S., Fuleihan, G.El-Hajj and Vieth, R. (2008). Vitamin D: A growing perspective. Clin. Lab. Sci., 45(4):339-415.

  • Koo, W.W. and Tsang, R. (1984). Bone mineralization in infants. Prog. Food Nutr. Sci., 8: 229–302.

  • Kovacs, C.S. (2008). Vitamin D in pregnancy and lactation: maternal, fetal and neonatal outcomes from human and animal studies. Am. J. Clin. Nutr. 88 : 520-528.

  • Kovacs, C.S., Woodland, M.L., Fudge, N.J. and Friel, J.K. (2005). The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer. Am. J. Physiol. Endocrinol. Metab., 289:133-144.

  • Kramer, M.S. (1987). ‘Determinants of low birth weight: Methodological assessment and meta-analysis’, Bull. World Health Organizat., 65(5): 663–737.

  • Maalouf, N.M. (2008). Mechanisms and functions of vitamin D. Curr. Opin. Nephrol. Hypertens, 17:408-415.

  • Mahon, P., Harvey, N., Crozier, S., Inskip, H., Robinson, S., Arden, N., Swaminathan, R., Cooper, C. and Godfrey, K. (2009). Low maternal vitamin D status and fetal bone development. J. Bone Miner. Res., 25 : 14-19.

  • Mallet, E., Gugi, B., Brunelle, P., Henocq, A., Basuyau, J.P. and Lemeur, H. (1986). Vitamin D supplementation in pregnancy: a controlled trial of two methods. Obstet. Gynecol., 68 (3): 300-304.

  • Mannion, C.A., Gray-Donald, K. and Koski, K.G. (2006). Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. CMAJ, 174: 1273-1277.

  • Marya, R.K., Rathee, S., Lata, V. and Mudgil, S. (1981). Effects of vitamin D supplementation in pregnancy. Gynecol. Obstet. Invest., 12: 155-161.

  • Maxwell, J.D., Ang, L., Brooke, O.G. and Brown, I.R. (1981). Vitamin D supplements enhance weight gain and nutritional status in pregnant Asians. Br. J. Obstet. Gynaecol., 88: 987-991.

  • McGrath, J.J., Burne, T.H. and Eyles, D.W. (2005). Seasonal variation in birth weight. CMAJ, 173: 733–734.

  • Namgung, R., Tsang, R.C., Specker, B.L., Sierra, R.I. and Ho, M.L. (1993). Reduced serum osteocalcin and 1,25dihydroxyvitamin D concentrations and low bone mineral content in small for gestational age infants: evidence of decreased bone formation rates. J. Pediatr., 122: 269-775.

  • Namgung, R., Tsang, R.C., Specker, B.L., Sierra, R.I. and Ho, M.L. (1994). Low bone mineral content and high serum osteocalcin and 1,25-dihydroxyvitamin D in summer- versus winter-born newborn infants: an early fetal effect? J. Pediatr. Gastroenterol. Nutr., 19: 220-227.

  • Norman, P., Moss, I., Sian, M., Gosling, M. and Powell, J. (2002). Maternal and postnatal vitamin D ingestion influences rat aortic structure, function and elastin content. Cardiovasc. Res., 55: 369-374.

  • Paunier, L., Lacourt, G., Pilloud, P., Schlaeppi, P., Sizonenko, P.C. (1978). 25-hydroxyvitamin D and calcium levels in maternal, cord and infant serum in relation to maternal vitamin D intake. Helv. Paediatr. Acta., 33 : 95-103.

  • Ponsonby, A.L., Lucas, R.M., Lewis, S. and Halliday, J. (2010). Vitamin D status during pregnancy and aspects of offspring health. Nutrients, 2 : 389-407.

  • Rummens, K., Van, B.R., Van, H.E., Zaman, Z., Bouillon, R.,Van, A.F.A. and Verhaeghe, J.(2002).Vitamin D deficiency in guinea pigs: exacerbation of bone phenotype during pregnancy and disturbed fetal mineralization, with recovery by 1,25(OH)2D3 infusion or dietary calciumphosphate supplementation. Calcif. Tissu. Internat.,71: 364– 375.

  • Scholl, T.O. and Chen, X. (2009). Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight. Early Hum. Dev., 85:231-234.

  • Selvin, S. and Janerich, D.T. (1971). Four factors influencing birth weight. Br. J. Prev. Soc. Med., 25: 12–16.

  • Smith, M.A., McHenry, C., Oslapas, R., Hofmann, C., Hessel, P. and Paloyan, E. (1989). Altered TSH levels associated with increased serum 1,25-dihydroxyvitamin D3: a possible link between thyroid and parathyroid disease. Surgery, 106 : 987-991.

  • Specker, B. (2004). Vitamin D requirements during pregnancy. Am. J. Clin. Nutr., 80: 1740-177.

  • Stevens, M.C., Fein, D.H. and Waterhouse, L.H. (2000). Season of birth effects in autism. J. Clin. Exp. Neuropsychol., 22 : 399-407.

  • Strand, C.E. and Ehrenkranz, R.A. (1994). Infants of diabetic mothers. In: Lebovitz HE (Ed.) Therapy for diabetes mellitus and related disorders. American Diabetes Association, Alexandria, VA, pp. 32–37.

  • Toda, T., Ito, M., Toda, Y., Smith, T. and Kummerow, F. (1985a). Angiotoxicity in swine of a moderate excess of dietary vitamin D3. Food Chem. Toxicol., 23: 585-592.

  • Toda, T., Toda, Y. and Kummerow, F.A. (1985b). Coronary arterial lesions in piglets from sows fed moderate excesses of vitamin D. Tohoku J. Exp. Med., 145 : 303-310.

  • Weiler, H., Fitzpatrick-Wong, S., Veitch, R., Kovacs, H., Schellenberg, J., McCloy, U. and Yuen, C.K. (2005). Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. CMAJ, 172 :757-761.

  • Wohlfahrt, J., Melbye, M., Christens, P., Andersen, A.M. and Hjalgrim, H. (1998). Secular and seasonal variation of length and weight at birth. Lancet, 352 (9145): 1990. World Health Organization (1992). International statistical classification of diseases and related health problems, tenth revision, World Health Organization, GENEVA


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  • Impact of Vitamin D Status during Gestation Period on Low Birth Weight

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Authors

Tanu Jain
Department of Food and Nutrition, College of Home Science, Punjab Agricultural University, Ludhiana (Punjab), India
Shikha Bathla
Department of Food and Nutrition, College of Home Science, Punjab Agricultural University, Ludhiana (Punjab), India

Abstract


Low birth weight has been defined by the World Health Organization (WHO) as weight at birth of less than 2,500 g. From conception to birth, the weight of human fetus increases six millions. This rapid growth requires a continuous supply of energy and nutrients which the fetus is unable to synthesize. Maternal socio-economic status, mother's nutrition and diet, lifestyle and other exposures including disease or complications such as hypertension can affect fetal growth and development. Maternal malnutrition causes birth weight reduction. A positive correlation has been seen between maternal and child vitamin D levels. Maternal vitamin D deficiency in early pregnancy has been associated with elevated risk of preterm birth or low birth weight. Low maternal vitamin D status may also slow neonatal cardiac development and alter brain morphology of infant. More recent studies may support the use of vitamin D supplementation during pregnancy to prevent LBW. Maternal total serum calcium levels decline as the pregnancy progresses but during the third trimester, the fetus maintains higher serum calcium levels as a result of active transport of the mineral across the placenta which leads to the low level of calcium in mother. Women at risk of vitamin D deficiency should be monitored and treated during pregnancy for vitamin D deficiency. LBW continues to be a problem of concern as disorders related to LBW and preterm birth are the leading causes of infant mortality. Studies are needed to investigate vitamin D requirements during pregnancy to derive guidelines for health professionals.

Keywords


Vitamin D, Low Birth Weight, Calcium.

References