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Effect of Sesamum indicum oil in Thyroidectomy-Induced Erectile Dysfunction in Rat
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The aim of the present study has been to explore the effect of Sesamum indicum in thyroidectomy-induced erectile dysfunction in rat. The animals were anaesthetized with combination of midazolam and ketamine i.p., and the thyroid gland was dissected out. The skin was then stitched and the wound was closed. Animals were treated with penicillin injection i.p. for 5 days postoperatively. After 45 days of surgery different groups of animals were treated with sesamum oil at dose levels 2 mL, 3 mL and 5 mL/kg p.o., and with standard drug sildenafil, respectively, for 28 days. At the end of the study erectile dysfunction-associated physical and biochemical parameters were evaluated to assess the effect of Sesamum indicum in thyroidectomy-induced erectile dysfunction. Thyroidectomy resulted in impairment of sexual function in the rat. Treatment of Sesamum indicum oil caused increase in testosterone level. It also produced significant positive effects on the physical parameters of sexual function such as mount latency, intromission latency, ejaculatory latency, post-ejaculatory interval, mount frequency and intromission frequency. Though the oil did not produce any significant effect on the levels of thyroid hormones, the oil at the doses of 2 mL, 3 mL and 5 mL/kg body weight restored sexual competence to a reasonable extent in which the highest dose produced the maximum response. A combination of Sesamum indicum oil and thyroxin may be recommended for hypothyroidism-associated sexual impairment.
Keywords
Erectile dysfunction, Sesamum indicum, Sesamum oil, Thyroidectomy, Thyroxine.
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- Singh R, Singh S, JeyabalanG, Ashraf A. An overview on traditional medicinal plants as aphrodisiac agent, J. Pharmacog. Phytochem. 2012; 1: 43–56.
- Padma NH, Hellstrom WJ, Kaiser FE, Labasky RF, Lue TF, Nolten WE, Norwood PC, Peterson CA, Shabsigh R, Tam TY, Place VA, Gesundheit N. Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. New Eng. J. Med. 1997; 336: 1–7.
- Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. New Eng. J. Med. 1992; 326: 90–94.
- Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J. Urol.1994 15: 54–61.
- Rampin O, Giuliano F. Brain control of penile erection. J. Urol. 2001; 19: 1–8.
- Giuliano F, Allard J,Apomorphine SL. Preclinical and clinical experiences learned from the first central nervous system-acting ED drug- review. Int. J. Impotence Res. 2002; 14: 53–64.
- Mulligan T, Schmitt B. Testosterone for erectile failure. J. Gen. Intern. Med.1993; 8: 517–521.
- Fazio L, Brock G. Erectile dysfunction management update. CMA. JAMC. 2004; 9: 1429–1437.
- Cauni V, Gutue SAlbu ES, Jinga V, Geavlete P. Diagnosis and treatment of erectile dysfunction-a pratical update. J. Med. Life. 2009; 2: 394–400.
- Jabaloyas JM. (2010) Hormonal etiology in erectile dysfunction. Arch. Esp. Urol. 2010; 63: 8: 621–627.
- Yakubu MT, Akanji MA, Oladiji AT. Male sexual dysfunction and methods used in assessing medicinal plants with aphrodisiac potentials. Pharmacog. Rev. 2007; 1: 49–56.
- Nzikou JM, Matos L, Bouanga-Kalou G, Ndangui CB, Pambou NPG, Kimbonguila A, Silou T, Linder M, Desobry S. Chemical composition of the seeds and oil of sesame (Sesamum indicum L.) grown in Congo-Brazzaville. Adv. J. Food. Sci. Technol. 2009; 1: 6–11.
- Hassan MAM. Studies on Egyptian sesame seeds (Sesamum indicum L.) and its products physicochemical analysis and phenolic acids of roasted Egyptian sesame seeds (Sesamum indicum L.). World J. Dairy Food Sci. 2012; 7: 195–201.
- Hirata F, Fujita K, Ishikura Y, Hosoda K, Ishikawa T, Nakamura H. Hypocholesterolemic effect of sesame lignin in humans atherosclerosis. 1996; 122: 135–136.
- Johnson J, Bratt B. M., Michel-Barron O, Glennow C, Tetruson B. Pure sesame oil vs isotonic sodium chloride solution as treatment for dry nasal mucosa. Arch. Otolaryngol. Head Neck Surg. 2001; 127: 1353–1356.
- Salerno M, Micillo M, Di Maio S, Capalbo D, Ferri P, Lettiero T. Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening, Eur. J. Endocrinol. 2001; 145:377–383.
- Sirato-Yasumoto S, Katsuta M, Okuyama Y, Takahashi Y, Ide T. Effect of sesame seeds rich in sesamin and sesamol in on fatty acid oxidation in rat liver. J. Agric. Food Chem. 2001; 49:2647–2651.
- Uma A, Anwar A, Ekta M. Anticonvulsant potentials of Sesamum indicum and Allium sativum oil alone and in combination in animal models. Int. J. Pharm. Pharmaceut. Sci. 2011; 3: 154–158.
- Amadi K, Sabo MA, Sagay AS. Thyroid hormone: The modulator of erectile function in the rabbit, Niger J. Physiol Sci. 2006; 21: 83–89.
- Srinivasan P, Liu MY. Comparative potential therapeutic effect of sesame oil and peanut oil against acute monocrotaline (Crotalaria) poisoning in a rat model. J. Vet. Intern. Med. 2012; 26: 491–499.
- Sharpe RM, McKinnell C, Kivlin C, Fisher JS. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 2006; 125: 769–784.
- Mendis-Handagama SM, Ariyaratne SHB. Leydig cells, thyroid hormones and steroidogenesis. Indian J. Exp. Biol. 2005; 43: 939–962.
- Maran RR. Thyroid hormones: their role in testicular steroidogenesis. Arch. Androl. 2003; 49: 375–388.
- Mackay S, Smith RA. Effects of growth factors on testicular morphogenesis. Int. Rev. Cytol. 2007; 260: 113–173.
- Montejo GAL, Llorca G, Izquierdo JA, Ledesma A, Bousono M, Calcedo A, Carrasco JL, Ciudad J, Daniel E, De GJ, Franco M, Gomez MJ, Macias JA, Martin T, Perez V, Sanchez S, Vicens E. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J. Sex. Marital Ther. 1997; 23: 176–194.
- Angulo J, Peiro C, Sanchez-Ferrer CF, Gabancho S, Cuevas P, Gupta S, Tejada IS. Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue. Br J Pharmacol. 2001; 134: 1190–1194.
- Gregorian RS, Golden KA, Bahce A, Goodman C, Kwong WJ, Khan ZM. Antidepressant-induced sexual dysfunction. Ann Pharmacother. 2002; 36: 1577–1589.
- Prabhakar D, Richard B. How do SSRIs cause sexual dysfunction? Curr Psychiatry 2010; 9: 30–34.
- Malviya N, Jain S, Gupta VB, Vyas S. Effect of garlic bulb on paroxetine-induced sexual dysfunction in male rats. Asian J Pharm Biol Res. 2011; 1: 218–221.
- Agmo A. Male rat sexual behaviour. Brain Res Protocol. 1997; 1:203-209.
- Yakubu MT, Akanji MA. Effect of aqueous extract of Massularia acuminate stem on sexual behaviour of male Wistar rats. Evid Based Complement Altern Med. 2011 Article ID 738103.
- Gauthaman K, Adaikan PG. The hormonal effects of Tribulus terrestris and its role in the management of erectile dysfunction: an evaluation using primates, rabbits and rats. Phytomedicine 2008; 15: 44–54.
- Subramoniam A, Madhavachandran V, Ravi K, Anuja VS. Aphrodisiac property of the elephant creeper Argyreia nervosa. J Endocrinol Reprod. 2007; 11: 82–85.
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