Journal of Endocrinology and Reproduction

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Pancreatic β-Cell Dysfunction in Diabetes


Affiliations
1 The Jackson Laboratory, Bar Harbor, 04609, Maine, United States
2 School of Science, Navrachana University, Vadodara 391410, Gujarat, India
     

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The decline in functional β-cell mass and β-cell dysfunction causes diabetes. Pancreatic β-cells play a fundamental role in controlling the glucose milieu, and β-cells of diabetic patients poorly respond to glucose. The mechanism underlying the pathology of impaired β-cell function is a unique challenge. This concise review summarizes the identity of β-cells during the progression and established diabetes. Understanding β-cell heterogeneity and the dynamic functional state during health and disease progression would be important for designing diabetes therapeutics to restore the β-cell mass by cellreplacement or regeneration approaches.

Keywords

β-Cell Dedifferentiation, β-Cell Dysfunction, β-Cell Identity.
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  • Pancreatic β-Cell Dysfunction in Diabetes

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Authors

Ansarullah
The Jackson Laboratory, Bar Harbor, 04609, Maine, United States
A. V. Ramachandran
School of Science, Navrachana University, Vadodara 391410, Gujarat, India

Abstract


The decline in functional β-cell mass and β-cell dysfunction causes diabetes. Pancreatic β-cells play a fundamental role in controlling the glucose milieu, and β-cells of diabetic patients poorly respond to glucose. The mechanism underlying the pathology of impaired β-cell function is a unique challenge. This concise review summarizes the identity of β-cells during the progression and established diabetes. Understanding β-cell heterogeneity and the dynamic functional state during health and disease progression would be important for designing diabetes therapeutics to restore the β-cell mass by cellreplacement or regeneration approaches.

Keywords


β-Cell Dedifferentiation, β-Cell Dysfunction, β-Cell Identity.

References





DOI: https://doi.org/10.18519/jer%2F2022%2Fv26%2F222218