Hypoglycemic Effect of Sialoadenectomy in Mice

One and three months old mice of both the sexes were sialoadenectomised and maintained under normal condition in the animal house upto the age of three and six months, respectively. During this period, their weight was recorded. Alloxan monohydrate was used to induce diabetes in some of them. Twenty four mice which were sialoadenectomised were subjected to fasting for 24 h and 36 h. Blood glucose, liver glycogen and alkaline phosphatase activity in liver, soleus muscle and kidney were determined in experimental and normal mice. The blood glucose level was considerably decreased in sialoadenectomised and sialoadenectomised diabetic mice compared to normal and diabetic cases. The decrease was much higher in the sialoadenectomised mice which were denied food for 24h and 36h. Glycogen content was decreased significantly in sialoadenectomised and sialoadenectomised diabetic mice. But in fasted sialoadenectomised mice, there was f6ss decrease than .fasted control. In sialoadenectomised and sialoadenectomised diabetic mice, alkaline phosphatase activity was decreased. The decrease was highly significant in liver and soleus muscle.