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The Biology of Leydig Cell Development


Affiliations
1 Center for Biomedical Research, Population Council, New York, NY 10021, United States
2 Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine Auburn University, 109 Greene, Hall, Auburn, AL 36849, United States
     

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Greater understanding of the growth factor regulation of Leydig cells during their postnatal differentiation has been achieved. Increasingly, attention will shift toward the goal of isolating Leydig stem cells because of their therapeutic potential in the treatment of male hypogonadism and the syndrome of androgen deficiency of aging males (ADAM). Markers of Leydig stem cells such as Kit receptor can be exploited in harvesting enriched fractions from the testis for amplification in vitro. When subsequently implanted back into the same testis, we expect the amplified stem cells to undergo differentiation into steroidogenic Leydig cells.

Keywords

Androgen Deficiency, Leydig Cell, Stem Cell, Steroidogenesis.
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  • The Biology of Leydig Cell Development

Abstract Views: 267  |  PDF Views: 0

Authors

Renshan Ge
Center for Biomedical Research, Population Council, New York, NY 10021, United States
Qiang Dong
Center for Biomedical Research, Population Council, New York, NY 10021, United States
Chantal Sottas
Center for Biomedical Research, Population Council, New York, NY 10021, United States
Enmeiniu
Center for Biomedical Research, Population Council, New York, NY 10021, United States
Benson T. Akingbemi
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine Auburn University, 109 Greene, Hall, Auburn, AL 36849, United States
Matthew P. Hardy
Center for Biomedical Research, Population Council, New York, NY 10021, United States

Abstract


Greater understanding of the growth factor regulation of Leydig cells during their postnatal differentiation has been achieved. Increasingly, attention will shift toward the goal of isolating Leydig stem cells because of their therapeutic potential in the treatment of male hypogonadism and the syndrome of androgen deficiency of aging males (ADAM). Markers of Leydig stem cells such as Kit receptor can be exploited in harvesting enriched fractions from the testis for amplification in vitro. When subsequently implanted back into the same testis, we expect the amplified stem cells to undergo differentiation into steroidogenic Leydig cells.

Keywords


Androgen Deficiency, Leydig Cell, Stem Cell, Steroidogenesis.



DOI: https://doi.org/10.18519/jer%2F2004%2Fv8%2F98731