Journal of Endocrinology and Reproduction

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Regulation of Rat Bone Marrow Stem Cells Differentiation into Osteoblasts and Mineralization by Estrogen


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1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
     

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The age-related defects in osteoblast number and function may be due to quantitative and qualitative stem cell defects. Early commitment and conversion of bone marrow stem cells (BMSCs) towards osteoblastic lineage is a critical step in the process of bone formation and bone remodeling, which is regulated by various systemic hormones and local factors. There are a few studies that analyze whether changes in the functional characteristics of osteoblastic progenitor cells, the BMSCs.
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  • Regulation of Rat Bone Marrow Stem Cells Differentiation into Osteoblasts and Mineralization by Estrogen

Abstract Views: 261  |  PDF Views: 0

Authors

S. Sitta-Djody
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
R. Ilangovan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
M. Balaganesh
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
N. Srinivasan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India

Abstract


The age-related defects in osteoblast number and function may be due to quantitative and qualitative stem cell defects. Early commitment and conversion of bone marrow stem cells (BMSCs) towards osteoblastic lineage is a critical step in the process of bone formation and bone remodeling, which is regulated by various systemic hormones and local factors. There are a few studies that analyze whether changes in the functional characteristics of osteoblastic progenitor cells, the BMSCs.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F98885