Journal of Endocrinology and Reproduction

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Effects of Experimental Diabetes and Insulin Replacement on Testicular Leydig Cells of Adult Rat


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1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
     

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Clinical and experimental studies have shown the adverse effects of diabetes on testicular steroidogenesis and spermatogenesis. The present study was designed to assess the effects of streptozotocin (STZ)-diabetes on Leydig cell LH receptors and steroidogenic enzymes. Diabetes was induced by single intraperitoneal injection of STZ at a dose of 65 mg/kg body weight. Induction of diabetes was confirmed by plasma insulin and glucose estimations. One set of diabetic rats was treated with insulin (3U/100g body weight/day in two equally divided doses), 3 days after STZ treatment. Control and experimental animals were killed after twenty days.
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  • Effects of Experimental Diabetes and Insulin Replacement on Testicular Leydig Cells of Adult Rat

Abstract Views: 274  |  PDF Views: 0

Authors

S. Yuvaraj
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
C. Parthasarathy
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
N. Srinivasan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
P. Govindarajulu
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
K. Balasubramanian
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India

Abstract


Clinical and experimental studies have shown the adverse effects of diabetes on testicular steroidogenesis and spermatogenesis. The present study was designed to assess the effects of streptozotocin (STZ)-diabetes on Leydig cell LH receptors and steroidogenic enzymes. Diabetes was induced by single intraperitoneal injection of STZ at a dose of 65 mg/kg body weight. Induction of diabetes was confirmed by plasma insulin and glucose estimations. One set of diabetic rats was treated with insulin (3U/100g body weight/day in two equally divided doses), 3 days after STZ treatment. Control and experimental animals were killed after twenty days.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F98894