Journal of Endocrinology and Reproduction

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Effect of Fluoxetine Hydrochloride on Fertility and Postnatal Development of Progeny of Female Wistar Rat


Affiliations
1 Department of Zoology, Ramnarain Ruia College, Matunga, Mumbai 400 019, India
2 Department of Zoology, Birla College of Arts, Science and Commerce, Murbad Road, Kalyan 421, India
     

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A Sub-acute toxicity study was conducted in adult female Wistar rats to study the effect of Fluoxetine Hydrochloride (Prozac) on reproductive behaviour, fertility and viability postnatal development of their progeny. 40 nulliparous depression induced female Wistar rats (11-12 weeks, weighing 150-170 gms) were divided into 4 groups and given Fluoxetine Hydrochloride at doses of 20mg/ kg, 40mg/kg, 60mg/kg and 80mg/kg intraperitoneally once daily for 14 days.
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  • Effect of Fluoxetine Hydrochloride on Fertility and Postnatal Development of Progeny of Female Wistar Rat

Abstract Views: 280  |  PDF Views: 0

Authors

A. J. Lillian
Department of Zoology, Ramnarain Ruia College, Matunga, Mumbai 400 019, India
S. Rohini
Department of Zoology, Ramnarain Ruia College, Matunga, Mumbai 400 019, India
U. Geeta
Department of Zoology, Birla College of Arts, Science and Commerce, Murbad Road, Kalyan 421, India

Abstract


A Sub-acute toxicity study was conducted in adult female Wistar rats to study the effect of Fluoxetine Hydrochloride (Prozac) on reproductive behaviour, fertility and viability postnatal development of their progeny. 40 nulliparous depression induced female Wistar rats (11-12 weeks, weighing 150-170 gms) were divided into 4 groups and given Fluoxetine Hydrochloride at doses of 20mg/ kg, 40mg/kg, 60mg/kg and 80mg/kg intraperitoneally once daily for 14 days.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F98948