Journal of Endocrinology and Reproduction

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Dose-Dependent Effects of Corticosterone on Leydig Cell LH Receptors and Steroidogenesis In vitro


Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
     

   Subscribe/Renew Journal


Glucocorticoid excess due to stress, endocrine disorders or therapeutic application has been recognized to have an adverse efTect on androgenic status of men. Our previous studies emphasized the defective LH signal transduction in Leydig cells exposed to corticosterone. The present study was designed to identify the dose-dependent effects of corticosterone on the regulation of Leydig cell surface LH receptors and steroidogenic potency in vitro.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 321

PDF Views: 0




  • Dose-Dependent Effects of Corticosterone on Leydig Cell LH Receptors and Steroidogenesis In vitro

Abstract Views: 321  |  PDF Views: 0

Authors

S. Rengarajan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
R. Sivakumar
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
N. Srinivasan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
P. Govindarajulu
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
K. Balasubramanian
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India

Abstract


Glucocorticoid excess due to stress, endocrine disorders or therapeutic application has been recognized to have an adverse efTect on androgenic status of men. Our previous studies emphasized the defective LH signal transduction in Leydig cells exposed to corticosterone. The present study was designed to identify the dose-dependent effects of corticosterone on the regulation of Leydig cell surface LH receptors and steroidogenic potency in vitro.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F98961