Effect of Diallyl Disulfide on Drug Metabolizing Enzymes against Aroclor-1254 Toxicity on Rat Primary Prostate Epithelial Cells

The cytochrome P450s are hemoproteins, which play critical role in the bioactivation and detoxicfication of a majority of xenobiotic substances such as drugs, environmental pollutants and dietary chemicals, and endogenous compounds such as steroids, fatty acids and prostaglandins. Environmental pollutants are main cause of several carcinogenesis, among these, polychlorinated biphenyls (PCB), are persistant environmental contaminants. Numerous epidemiological and experimental studies imply that garlic can be considered as a dietary anticarcinogenic component.