Biochemical and Hormonal Profiles in Selected Normal, Untreated and Treated Type-2 (Non-Insulin Dependent) Diabetic Men and Menopausal Women

This study was designed to understand the biochemical and hormonal changes associated with type-2 diabetes in South Indian men and menopausal women. Three groups of subjects were recruited for the study viz., age-matched normal (control), untreated and treated type-2 diabetic men and menopausal women. Untreated type-2 diabetic men had low levels of serum testosterone with unalteredestradiol and elevated insulin and Cortisol. Oral hypoglycemic agents did not influence serum insulin level but decreased the Cortisol with no change in testosterone and estradiol levels. Among biochemical parameters, blood glucose, glycosylated hemoglobin, triglycerides and creatinine were higher in both treated and untreated type-2 diabetic men. The levels of the HDL and LDL did not reflect any significant change.