Journal of Endocrinology and Reproduction

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Role of RhTGF-β1 on Differentiation and Mineralization of Rat Bone Marrow Stem Cells


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1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
     

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Bone marrow is a complex tissue, which contains stem cells for haematopoietic and mesenchymal lineage. Among various growth factors that regulate bone remodeling, TGF-bl is the major growth fator, which is synthesized and stored in bone in large amount. But, the exact role of TGF-bl on the differentiation and mineralization of bone marrow stem cells (BMSCs) is still not clear. Hence, the present study is designed to delineate the role of rhTGF-bl on the differentiation and mineralization of rat BMSC in vitro. Bone marrow stem cells were isolated from the femur bones of healthy rats and cultured with osteogenic medium (OM).
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  • Role of RhTGF-β1 on Differentiation and Mineralization of Rat Bone Marrow Stem Cells

Abstract Views: 258  |  PDF Views: 0

Authors

E. Thirupavai
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
S. Veni
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
S. Sitta Djody
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
R. Ilangovan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
M. Balaganesh
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
N. Srinivasan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India

Abstract


Bone marrow is a complex tissue, which contains stem cells for haematopoietic and mesenchymal lineage. Among various growth factors that regulate bone remodeling, TGF-bl is the major growth fator, which is synthesized and stored in bone in large amount. But, the exact role of TGF-bl on the differentiation and mineralization of bone marrow stem cells (BMSCs) is still not clear. Hence, the present study is designed to delineate the role of rhTGF-bl on the differentiation and mineralization of rat BMSC in vitro. Bone marrow stem cells were isolated from the femur bones of healthy rats and cultured with osteogenic medium (OM).


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F99254